CAS 346-18-9|polythiazide (200 mg)
Introduction：Basic information about CAS 346-18-9|polythiazide (200 mg), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | polythiazide (200 mg) | ||
|---|---|---|---|
| CAS Number | 346-18-9 | Molecular Weight | 439.88200 |
| Density | 1.598g/cm3 | Boiling Point | 580.1ºC at 760mmHg |
| Molecular Formula | C11H13ClF3N3O4S3 | Melting Point | 202.5° |
| MSDS | / | Flash Point | 304.7ºC |
Names
| Name | 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide |
|---|---|
| Synonym | More Synonyms |
polythiazide (200 mg) BiologicalActivity
| Description | Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
| In Vitro | Polythiazide (500 μM, 1 min) induces significant phototoxic NHIK 3025 cell death under Bluelight 2000 apparatus (Ex: 325 nM)[2]. |
| In Vivo | Polythiazide (oral gavage, 10 mg/kg, daily for 5 days) Increased plasma cholesterol levels in Cholesterol-fed C57BL/cdJ mouse[3]. Polythiazide (Oral administration, 0.4 mg/k g) shows diuretic and saluretic effects in hypertensive dogs and rats[1]. Animal Model: Cholesterol-fed C57BL/cdJ mice[3] Dosage: 10 mg/kg Administration: Oral gavage, daily for 5 days Result: Caused approximately 13% rise in total plasma cholesterol levels, and increased non-HDL lipoprotein fraction. Animal Model: Hypertensive dogs[1] Dosage: 0.4 mg/kg Administration: Oral administration, daily for 5 days Result: Increased in excretion of sodium and chloride. Animal Model: Hypertensive rats[1] Dosage: 0.05, 0.1, 0.2, 0.4 mg/k g Administration: Oral administration, twice a day for 3 days. Result: Displayed natriuretic and chloruretic effects. |
| References | [1]. A SCRIABINE, et al. Pharmacological studies with polythiazide, a new diuretic and antihypertensive agent. Proc Soc Exp Biol Med. 1961 Aug-Sep;107:864-72. [2]. E Selvaag, et al. Phototoxicity due to sulphonamide derived oral antidiabetics and diuretics: investigations in a cell culture model. Photodermatol Photoimmunol Photomed. 1996 Feb;12(1):1-6. [3]. M N Krupp, et al. Effects of doxazosin and other antihypertensives on serum lipid levels and lipoprotein lipase in the C57BR/cdJ mouse. J Cardiovasc Pharmacol. 1989;13 Suppl 2:S11-8; discussion S18-9. |
Chemical & Physical Properties
| Density | 1.598g/cm3 |
|---|---|
| Boiling Point | 580.1ºC at 760mmHg |
| Melting Point | 202.5° |
| Molecular Formula | C11H13ClF3N3O4S3 |
| Molecular Weight | 439.88200 |
| Flash Point | 304.7ºC |
| Exact Mass | 438.97100 |
| PSA | 151.63000 |
| LogP | 4.59280 |
| Index of Refraction | 1.566 |
| InChIKey | CYLWJCABXYDINA-UHFFFAOYSA-N |
| SMILES | CN1C(CSCC(F)(F)F)Nc2cc(Cl)c(S(N)(=O)=O)cc2S1(=O)=O |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 300 ug/kg/5D-I
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - coma Nutritional and Gross Metabolic - other changes
- REFERENCE :
- AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 70,1163,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,793,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969
Synonyms
| Polythiazide |
| Polythiazidum |
| Politiazida |
| Nephril |
| P-2525 |
| Renese |
| Drenusil |
