Introduction：Basic information about CAS 4707-47-5|Atraric acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Atraric acid |
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| CAS Number | 4707-47-5 | Molecular Weight | 196.200 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 360.7±22.0 °C at 760 mmHg |
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| Molecular Formula | C10H12O4 | Melting Point | 141-146 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 143.9±15.8 °C |
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Names
| Name | Veramoss |
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| Synonym | More Synonyms |
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Atraric acid BiologicalActivity
| Description | Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Immunology/Inflammation >>NO SynthaseSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Others >>Androgen Receptor |
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| Target | Androgen receptor, NO synthesis, MAPK-NFκB pathway[1][2] |
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| In Vitro | Atraric acid (10 μM; CV1 cells) represses the transactivation function mediated by Dihydrotestosterone-induced human AR[1]. Atraric acid (10 μM; PCa cells) inhibits the expression of the PSA gene in both androgen-dependent and androgen-independent PCa cells[1]. Atraric acid (1-300 μM; 24 h) dose-dependently inhibits pro-inflammatory cytokine, nitric oxide, prostaglandin E2 in LPS-stimulated RAW264.7 cells, but does not influence the cell viability[2]. Atraric acid (100 and 300 μM; 18 h or 4 h) downregulates the expression of phosphorylated IκB, extracellular signal-regulated kinases (ERK) and nuclear factor kappa B (NFκB) signaling pathway to exhibit anti-inflammatory effects in LPS-stimulated RAW264.7 cells[2]. Cell Viability Assay[2] Cell Line: RAW264.7 cells Concentration: 1-300 μM Incubation Time: 24 h Result: Did not influence the cell viability. Western Blot Analysis[2] Cell Line: RAW264.7 cells Concentration: 100 and 300 μM Incubation Time: 18 h or 4 h Result: Inhibited LPS-Induced expression of iNOS and COX-2 in a dose-dependent manner. Suppressed LPS-stimulated phosphorylation of the Nfκb signaling pathway. |
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| In Vivo | Atraric acid (10, 30 mg/kg; i.p.; single dosage) inhibits the production of pro-inflammatory cytokines and reduces pathological damages in LPS-induced endotoxin shock mice[2]. Animal Model: Female BALB/c mice (7 weeks old, 17-20 g; LPS-induced endotoxin shock)[2] Dosage: 10, 30 mg/kg Administration: i.p.; single dosage Result: Inhibited the production of pro-inflammatory cytokines. Reduced pathological damages such as vasodilation and bleeding. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 360.7±22.0 °C at 760 mmHg |
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| Melting Point | 141-146 °C(lit.) |
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| Molecular Formula | C10H12O4 |
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| Molecular Weight | 196.200 |
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| Flash Point | 143.9±15.8 °C |
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| Exact Mass | 196.073563 |
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| PSA | 66.76000 |
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| LogP | 2.84 |
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| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
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| Index of Refraction | 1.570 |
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| InChIKey | UUQHKWMIDYRWHH-UHFFFAOYSA-N |
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| SMILES | COC(=O)c1c(C)cc(O)c(C)c1O |
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Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 2 |
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| HS Code | 2918199090 |
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Customs
| HS Code | 2918199090 |
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| Summary | 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| QR CQ B1 E1 DVO1 |
| EINECS 225-193-0 |
| METHYL 2,4-DIHYDROXY-3,6-DIMETHYLBENZOATE |
| Methyl atratate |
| MFCD00157202 |
| Benzoic acid, 2,4-dihydroxy-3,6-dimethyl-, methyl ester |
| 2,4-Dihydroxy-3,6-dimethylbenzoic acid methyl ester |
