Introduction：Basic information about CAS 58-49-1|(Val5)-Angiotensin II, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (Val5)-Angiotensin II |
|---|
| CAS Number | 58-49-1 | Molecular Weight | 1032.15 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C49H69N13O12 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | [Val5] Angiotensin II, human |
|---|
| Synonym | More Synonyms |
|---|
(Val5)-Angiotensin II BiologicalActivity
| Description | Angiotensin II 5-valine is an agonist of angiotensin receptor. |
|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Angiotensin ReceptorResearch Areas >>CancerPeptides |
|---|
| Target | Angiotensin receptor[1]. |
|---|
| In Vivo | By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1]. |
|---|
| Animal Admin | Rats[1] Male Sprague Dawley rats are uninephrectomized and divided into three groups: control (n=6), Angiotensin II 5-valine (exogenous form) infused (n=8), and Angiotensin II 5-valine infused rats treat with losartan (n=8). Angiotensin II 5-valine, which has the same biological and immunoreactive properties as endogenous ANG II, was infused at 40 ng/min via an osmotic minipump implant subcutaneously[1]. |
|---|
| References | [1]. Zou LX et al. Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens. 1998 May;11(5):570-8. |
|---|
Chemical & Physical Properties
| Molecular Formula | C49H69N13O12 |
|---|
| Molecular Weight | 1032.15 |
|---|
| PSA | 443.64000 |
|---|
| LogP | 2.77030 |
|---|
| InChIKey | JVCJXRGXGITABA-IAQGTVMASA-N |
|---|
| SMILES | CC(=O)O.CC(C)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(N)CC(=O)O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)O)C(C)C |
|---|
| Storage condition | -20°C |
|---|
Synonyms
| DRVYVHPF |
| (5-L-Val)-Angiotensin II |
| Angiotensin Acetate |
| L-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE |
| <Val5>-angiotensin II |
| ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE |
| [Asp(1),Val(5)]angiotensin II |
| H-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH |
| [VAL5] ANGIOTENSIN II HUMAN |
| ANGIOTENSIN II,5-L-VALINE |
| [val5]-angiotensin ii acetate hydrate |
| Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH |
| Angiotensin II 5-valine |
