Introduction：Basic information about CAS 58337-35-2|H9M2E, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H9M2E |
|---|
| CAS Number | 58337-35-2 | Molecular Weight | 336.38400 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C20H20N2O3 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | 2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium-9-ol,acetate |
|---|
| Synonym | More Synonyms |
|---|
H9M2E BiologicalActivity
| Description | Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used in cancer research, particularly in metastatic breast cancer[1][2]. |
|---|
| Related Catalog | Research Areas >>Cancer |
|---|
| Target | Nucleic acids[1][2]. |
|---|
| In Vitro | Elliptinium (0.35 µM; 1 h) (9-OH-NME3) shows highly stable covalent bonding to nucleic acids of L1210 cells[1]. Cell Viability Assay[1] Cell Line: L1 210 cells Concentration: 0.35 µM Incubation Time: 1 h Result: Exhibited highly stable covalent bonding to DNA and RNA. Showed no reversal of binding as cells went on replicating during a 40-h period. |
|---|
Chemical & Physical Properties
| Molecular Formula | C20H20N2O3 |
|---|
| Molecular Weight | 336.38400 |
|---|
| Exact Mass | 336.14700 |
|---|
| PSA | 80.03000 |
|---|
| LogP | 2.37740 |
|---|
| InChIKey | BOMZMNZEXMAQQW-UHFFFAOYSA-N |
|---|
| SMILES | CC(=O)[O-].Cc1c2cc[n+](C)cc2c(C)c2c1[nH]c1ccc(O)cc12 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UU8875500
- CHEMICAL NAME :
- 6H-Pyrido(4,3-b)carbazolium, 9-hydroxy-2,5,11-trimethyl-, acetate
- CAS REGISTRY NUMBER :
- 58337-35-2
- LAST UPDATED :
- 199609
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C18-H17-N2-O.C2-H3-O2
- MOLECULAR WEIGHT :
- 336.42
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 33 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 40 mg/kg/8W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 89,281,1987
|
Synonyms
| ELLIPTINIUM ACETATE |
| Ellipticine acetomethylate |
| 9-hydroxy-2-methylellipticinium acetate |
| elliptinium |
| Elliptinii acetas [INN-Latin] |
| EINECS 261-216-0 |
| Acetato de eliptinio [INN-Spanish] |
| Acetate d'elliptinium [INN-French] |
| Celiptium |
| 9-hydroxy-N-2-methylellipticinium acetate |
| Elliptinium acetate [INN:BAN] |
| N2-Methylhydroxyellipticinium acetate |
| N2-methyl-9-hydroxyellipticinium acetate |
