Introduction：Basic information about CAS 32421-46-8|Bunaftide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bunaftide |
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| CAS Number | 32421-46-8 | Molecular Weight | 326.47600 |
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| Density | 1.026g/cm3 | Boiling Point | 476ºC at 760 mmHg |
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| Molecular Formula | C21H30N2O | Melting Point | / |
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| MSDS | / | Flash Point | 192ºC |
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Names
| Name | N-butyl-N-[2-(diethylamino)ethyl]naphthalene-1-carboxamide |
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| Synonym | More Synonyms |
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Bunaftide BiologicalActivity
| Description | Bunaftide (Bunaftine; Bunaphtide; Meregon) is an antiarrhythmic agent. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease |
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| In Vitro | At concentrations of 0.5-2.0 mM, Bunaftide causes contraction and rounding of the cells with loss of microvilli-like processes. Aggregates of dense, partly granular, partly fibrillar material form in the cytoplasm and the rough endoplasmic reticulum became vesiculated. Bundles of actin filaments are disrupted, forming rings, coils, and granules. 0.4 mM Bunaftide increases and 0.8-1.0 mM markedly decreases the percentage of mitotic cells, without accumulation of cells in any particular stage of mitosis. The drug may arrest the cell cycle at some point before mitosis; it may have a critical concentration above which the arrest becomes permanent[1]. Bunaftide at 1, 5 and 10 mg/L produces a concentration-dependent depression of the maximum rate of rise of the action potential in guinea pig papillary muscle preparations without affecting the resting membrane potential and the action potential amplitude. The action potential duration (APD50, APD90) is significantly prolonged by the treatment with 1 and 5 mg/L Bunaftide, while it is not changed by the treatment with 10 mg/L[2]. |
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| Cell Assay | Human embryonic fibroblasts and HeLa cells are seeded into 35-mm plastic Petri dishes at a density of 1x105 cells/cm2. Bunaftide is used in final concentrations of 0.1-2.0 mM. The cells are exposed to the drug for periods ranging from 15 min to 24 h. To allow the cells to recover, the Bunaftide medium is removed and the cultures are left in standard medium for 4-24 h[1]. |
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| References | [1]. Moskalewski S, et al. Effects of bunaftine on morphology, microfilament integrity, and mitotic activity in cultured human fibroblasts and HeLa cells. Cell Tissue Res. 1984;236(1):107-15. [2]. Kimura T, et al. Electrophysiological effects of bunaftine, an antiarrhythmic drug, on action potential characteristics in ventricular muscle preparations. Nihon Yakurigaku Zasshi. 1986 Jul;88(1):1-7. |
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Chemical & Physical Properties
| Density | 1.026g/cm3 |
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| Boiling Point | 476ºC at 760 mmHg |
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| Molecular Formula | C21H30N2O |
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| Molecular Weight | 326.47600 |
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| Flash Point | 192ºC |
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| Exact Mass | 326.23600 |
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| PSA | 23.55000 |
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| LogP | 4.42390 |
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| Index of Refraction | 1.562 |
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| InChIKey | WWGZXRYELYWJBD-UHFFFAOYSA-N |
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| SMILES | CCCCN(CCN(CC)CC)C(=O)c1cccc2ccccc12 |
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| Storage condition | 2-8℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- QJ1890000
- CHEMICAL NAME :
- 1-Naphthalenecarboxamide, N-butyl-N-(2-(diethylamino)ethyl)-
- CAS REGISTRY NUMBER :
- 32421-46-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C21-H30-N2-O
- MOLECULAR WEIGHT :
- 326.53
- WISWESSER LINE NOTATION :
- L66J BVN4&2N2&2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 122 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,226,1989
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Safety Information
Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| EINECS 251-027-1 |
| Bunaftina [INN-Spanish] |
| Bunaphtide |
| Bunaphtine |
| Bunaftinum [INN-Latin] |
| Bunaftine |
| Bunaftine (INN) |
| N-Butyl-N-(2-(diethylamino)ethyl)-1-naphthamide |
| N-(2-Diethylaminoethyl)-N-n-butyl-1-naphthamid |
| Bunaftide |
