CAS 524-83-4|Ethybenztropine
Introduction：Basic information about CAS 524-83-4|Ethybenztropine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ethybenztropine | ||
|---|---|---|---|
| CAS Number | 524-83-4 | Molecular Weight | 321.45600 |
| Density | 1.1g/cm3 | Boiling Point | 422.8ºC at 760mmHg |
| Molecular Formula | C22H27NO | Melting Point | / |
| MSDS | / | Flash Point | 124ºC |
Names
| Name | Etybenzatropine |
|---|---|
| Synonym | More Synonyms |
Ethybenztropine BiologicalActivity
| Description | Ethybenztropine (Ponalid) is a muscarinic receptor blocker. Ethybenztropine is an anticholinergic and antihistaminergic agent[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Neurological Disease |
| Target | Muscarinic Receptor[1] |
| In Vitro | Ethybenztropine (10 μM) inhibits the uptake of 3H-DA in neostriatal slices. |
| In Vivo | Ethybenztropine (25 μg, microinjected into mesencephalic NRM) blocks the hypertherrnic response of carbachol microinjection into nucleus raphe median (NRM) of rabbits[1]. Ethybenztropine (30-60 μg/kg, administered by the fourth ventricle) is effective in preventing arrhythmias in dogs[2]. Ethybenztropine (50 mg/kg, i.p.) reduces the catecholamines accumulation in rats[3]. Animal Model: Dogs with cardiac arrhythmias[2] Dosage: 30-60 μg/kg Administration: Administered by the fourth ventricle Result: Produced slight hypotension (never exceeding a fall of 25 mm Hg) and slight sinus tachycardia. Converted arrhythmias to sinus rhythms. |
| References | [1]. A K Saxena, et al. Presence of cholinoceptors in mesencephalic raphe nuclei concerned in thermoregulation in rabbits. Clin Exp Pharmacol Physiol. 1984 Mar-Apr;11(2):105-10. [2]. M Rozear, et al. Effects of intracerebroventricular l-hyoscyamine, ethybenztropine and procaine on cardiac arrhythmias induced in dogs by pentylenetetrazol, picrotoxin or deslanoside. Int J Neuropharmacol. 1968 Jan;7(1):1-6. [3]. LARS-OVE FARNEBO, et al. Effect of some antiparkinsonian drugs on catecholamine neurons. Journal of Pharmacy and Pharmacology, 1970, 22(10): 733-737. |
Chemical & Physical Properties
| Density | 1.1g/cm3 |
|---|---|
| Boiling Point | 422.8ºC at 760mmHg |
| Molecular Formula | C22H27NO |
| Molecular Weight | 321.45600 |
| Flash Point | 124ºC |
| Exact Mass | 321.20900 |
| PSA | 12.47000 |
| LogP | 4.74580 |
| Index of Refraction | 1.597 |
| InChIKey | PHTMLLGDZBZXMW-WCRBZPEASA-N |
| SMILES | CCN1C2CCC1CC(OC(c1ccccc1)c1ccccc1)C2 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 560 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,228,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #2235M
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 66 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,228,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - parasympatholytic
- REFERENCE :
- EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 9,304,1970
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 215 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,228,1972
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 6 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,228,1972
Safety Information
| HS Code | 2933990090 |
|---|
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Synonyms
| Ponalide |
| UK-738 |
| ethybenztropine |
| VK-738 |
| Ethylbenatropine |
