CAS 480-44-4|Acacetin
Introduction：Basic information about CAS 480-44-4|Acacetin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Acacetin | ||
|---|---|---|---|
| CAS Number | 480-44-4 | Molecular Weight | 284.263 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 518.6±50.0 °C at 760 mmHg |
| Molecular Formula | C16H12O5 | Melting Point | 260-265 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 198.3±23.6 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 5,7-dihydroxy-4'-methoxyflavone |
|---|---|
| Synonym | More Synonyms |
Acacetin BiologicalActivity
| Description | 1) Natural acacetin was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.[1]2) Acacetin significantly suppressed the photoreceptor collapse. [1]3) Acacetin significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. [1]4) Acacetin inhibited the generation of the APP-CTF by affecting APP cleavage. [1]5) Acacetin prolongs lifespan of significantly in the dose dependent manner. Acacetin(25 uM) had the greatest effect on longevity, extending mean lifespan significantly by 27.31% at 25 uM concentration |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Potassium ChannelNatural Products >>FlavonoidsResearch Areas >>Others |
| References | [1]. Wang X. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophilamodels of Alzheimer's disease. Sci Rep, 2015 Nov 4, 5:16127. [2]. Asthana J et al. Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res, 2016 Aug, 50(8):861-74. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 518.6±50.0 °C at 760 mmHg |
| Melting Point | 260-265 °C(lit.) |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.263 |
| Flash Point | 198.3±23.6 °C |
| Exact Mass | 284.068481 |
| PSA | 79.90000 |
| LogP | 3.15 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.669 |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 933 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 933 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 50 mg/kg
- SEX/DURATION :
- female 1 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DJ3002000 |
| HS Code | 2914509090 |
Customs
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| Linarigenin |
| 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one |
| 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
| Acacetin |
| 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one |
| 5,7-Dihydroxy-4'-methoxyflavone |
| Apigenin-4'-methyl Ether |
| 4'-O-Methylapigenin |
| Buddleoflavonol |
| MFCD00016936 |
| 4'-Methoxyapigenin |
| 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-methoxyphenyl)- |
| Apigenin 4'-methyl ether |
| EINECS 207-552-3 |
