CAS 5875-06-9|Proparacaine Hydrochloride
| Common Name | Proparacaine Hydrochloride | ||
|---|---|---|---|
| CAS Number | 5875-06-9 | Molecular Weight | 330.850 |
| Density | / | Boiling Point | 434.4ºC at 760mmHg |
| Molecular Formula | C16H27ClN2O3 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 216.5ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Proxymetacaine Hydrochloride |
|---|---|
| Synonym | More Synonyms |
Proparacaine Hydrochloride BiologicalActivity
| Description | Proparacaine Hydrochloride is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.IC50 Value: 3.4 mM(ED50) [1]Target: Sodium Channelin vitro: Proparacaine is more potent and less toxic than cocaine [1]. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used [2].in vivo: Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton [3]. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade [4]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Neurological DiseaseNatural Products >>Others |
| References | [1]. Grant, R.L. and D. Acosta, Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells. Exp Eye Res, 1994. 58(4): p. 469-78. [2]. Segarra, S., K. Papasouliotis, and C. Helps, The in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections. Vet Ophthalmol, 2011. 14 Suppl 1: [3]. Dass, B.A., H.K. Soong, and B. Lee, Effects of proparacaine on actin cytoskeleton of corneal epithelium. J Ocul Pharmacol, 1988. 4(3): p. 187-94. [4]. Hung, C.H., et al., Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci Lett, 2009. 454(3): p. 249-53. |
Chemical & Physical Properties
| Boiling Point | 434.4ºC at 760mmHg |
|---|---|
| Molecular Formula | C16H27ClN2O3 |
| Molecular Weight | 330.850 |
| Flash Point | 216.5ºC |
| Exact Mass | 330.171021 |
| PSA | 64.79000 |
| LogP | 3.93940 |
| InChIKey | BFUUJUGQJUTPAF-UHFFFAOYSA-N |
| SMILES | CCCOc1ccc(C(=O)OCCN(CC)CC)cc1N.Cl |
| Storage condition | -20°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 64 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 40,133,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3371 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,269,1958 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3223 No. of Facilities: 412 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3442 (estimated) No. of Female Employees: 2127 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H317-H319-H332 |
| Precautionary Statements | P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R20/21/22;R36;R43 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DG3065000 |
Articles71
More Articles| Enhanced Retinal Ganglion Cell Survival in Glaucoma by Hypoxic Postconditioning After Disease Onset. Neurotherapeutics 12(2) , 502-14, (2015) The neuroprotective efficacy of adaptive epigenetics, wherein beneficial gene expression changes are induced by nonharmful "conditioning" stimuli, is now well established in several acute, preclinical... | |
| Differential bacterial gene expression during experimental pneumococcal endophthalmitis. Ophthalmic Res. 53(3) , 149-61, (2015) Streptococcus pneumoniae (pneumococcus) is a potential cause of bacterial endophthalmitis in humans that can result in ocular morbidity. We sought to identify pneumococcal genes that are differentiall... | |
| Intraocular pharmacokinetics of intravitreal vascular endothelial growth factor-Trap in a rabbit model. Eye (Lond.) 29(4) , 561-8, (2015) To determine intraocular pharmacokinetic properties of intravitreally injected vascular endothelial growth factor (VEGF)-Trap in a rabbit model.VEGF-Trap was intravitreally injected in 18 rabbit eyes.... |
Synonyms
| EINECS 227-541-7 |
| 3-amino-4-propoxybenzoate de 2-(diéthylamino)éthyle chlorhydrate |
| 2-(Diethylamino)ethyl-3-amino-4-propoxybenzolcarboxylathydrochlorid |
| Proxymetacaine Hydrochloride |
| Proxymetacaine Hcl |
| 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride (1:1) |
| Benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, hydrochloride (1:1) |
| 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate,hydrochloride |
| PROPARACAINE HCL |
| Proparacaine hydrochloride |
| MFCD00083467 |
| 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride |
| ak-taine |
