CAS 7753-60-8|Anecortave Acetate

Introduction：Basic information about CAS 7753-60-8|Anecortave Acetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameAnecortave Acetate
CAS Number7753-60-8Molecular Weight386.48100
Density1.23g/cm3Boiling Point551.8ºC at 760 mmHg
Molecular FormulaC23H30O5Melting Point/
MSDS/Flash Point188.4ºC

Names

Name[2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
SynonymMore Synonyms

Anecortave Acetate BiologicalActivity

DescriptionAnecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].
Related CatalogSignaling Pathways >>Metabolic Enzyme/Protease >>PAI-1Research Areas >>Cardiovascular Disease
Target

PAI-1[2]

In VivoAnecortave acetate (5 μl of a 10% suspension; Injected into eyes) significantly inhibits pathologic retinal angiogenesis and increases PAI-1 mRNA levels[2]. Animal Model: Sprague-Dawley albino rats (intravitreally injected with premixed antibiotics to influence retinal vessel growth)[2] Dosage: 5 μl of a 10% suspension of Anecortave acetate Administration: Injected into eyes Result: significantly inhibited pathologic retinal angiogenesis in this model, while not significantly affecting normal intraretinal vessels. Increased 6-to-9-fold PAI-1 mRNA at 1 to 3 days after injection.

Chemical & Physical Properties

Density1.23g/cm3
Boiling Point551.8ºC at 760 mmHg
Molecular FormulaC23H30O5
Molecular Weight386.48100
Flash Point188.4ºC
Exact Mass386.20900
PSA80.67000
LogP3.30170
Index of Refraction1.572
InChIKeyYUWPMEXLKGOSBF-GACAOOTBSA-N
SMILESCC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3=CCC21C

Synonyms

2-((10S,13S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
21-Acetoxy-17-hydroxy-pregna-4,9(11)-dien-3,20-dion
Retaane
21-acetoxy-17-hydroxy-pregna-4,9(11)-diene-3,20-dione
AL-3789
2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Anecortave
Anecortave acetate
Retaane suspension
CAS 571-22-2|(5R,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15
CAS 5434-23-1|N,N-dimethyl-5H-purine-2,6-diamine
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