CAS 58433-11-7|Tilomisole

Introduction：Basic information about CAS 58433-11-7|Tilomisole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tilomisole BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Tilomisole
CAS Number	58433-11-7	Molecular Weight	342.79900
Density	1.51g/cm3	Boiling Point	/
Molecular Formula	C₁₇H₁₁ClN₂O₂S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	2-[1-(4-chlorophenyl)-[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid
Synonym	More Synonyms

Tilomisole BiologicalActivity

Description	Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation[1][2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
References	[1]. Dillman RO, et al. WY 18,251 (Tilomisole), an analog of levamisole: tolerability, and immune modulating effects in cancer patients. Mol Biother. 1992;4(1):10-14. [2]. Darwish SA, et al. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105644.

Description

Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation[1][2].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology

References

[1]. Dillman RO, et al. WY 18,251 (Tilomisole), an analog of levamisole: tolerability, and immune modulating effects in cancer patients. Mol Biother. 1992;4(1):10-14.

[2]. Darwish SA, et al. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105644.

Chemical & Physical Properties

Density	1.51g/cm3
Molecular Formula	C₁₇H₁₁ClN₂O₂S
Molecular Weight	342.79900
Exact Mass	342.02300
PSA	82.84000
LogP	4.49650
Index of Refraction	1.746
InChIKey	PUYFLGQZLHVTHX-UHFFFAOYSA-N
SMILES	O=C(O)Cc1sc2nc3ccccc3n2c1-c1ccc(Cl)cc1

Synonyms

Tilomisol

Tilomisol [Spanish]

Tilomisole (USAN/INN)

Tilomisolum

3 (4 chlorophenyl)thiazolo[3,2 a]benzimidazole 2 acetic acid

3-(p-chlorophenyl)-thiazolo[3,2-a]benzimidazole-2-acetic acid

Tilomisolum [Latin]

[3-(4-chloro-phenyl)-benzo[4,5]imidazo[2,1-b]thiazol-2-yl]-acetic acid

TILOMISOLE

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