CAS 796073-69-3|DM4

Introduction：Basic information about CAS 796073-69-3|DM4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. DM4 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	DM4
CAS Number	796073-69-3	Molecular Weight	780.36700
Density	1.29±0.1 g/cm3	Boiling Point	943.2±65.0 °C
Molecular Formula	C₃₈H₅₄ClN₃O₁₀S	Melting Point	185-187 °C (decomp)
MSDS	/	Flash Point	/

Names

Name	N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine
Synonym	More Synonyms

DM4 BiologicalActivity

Description	DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate.
Related Catalog	Signaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/TubulinResearch Areas >>Cancer
In Vitro	DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1].
References	[1]. Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.

Chemical & Physical Properties

Density	1.29±0.1 g/cm3
Boiling Point	943.2±65.0 °C
Melting Point	185-187 °C (decomp)
Molecular Formula	C₃₈H₅₄ClN₃O₁₀S
Molecular Weight	780.36700
Exact Mass	779.32200
PSA	195.27000
LogP	5.39690
InChIKey	JFCFGYGEYRIEBE-VBWUFBETSA-N
SMILES	COc1cc2cc(c1Cl)N(C)C(=O)CC(OC(=O)C(C)N(C)C(=O)CCC(C)(C)S)C1(C)OC1C(C)C1CC(O)(NC(=O)O1)C(OC)C=CC=C(C)C2

Safety Information

Hazard Codes	T+

Synonyms

l-dm4

n2'-deacetyl-n2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine

DM4

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