Introduction：Basic information about CAS 7730-20-3|UNII:3I7LZ8M32B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
6-Fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase, produced a transient disruption of sleep in rats chronically implanted with EEG recording electrodes[1].
Related Catalog
Signaling Pathways >>Metabolic Enzyme/Protease >>Tryptophan HydroxylaseResearch Areas >>Neurological Disease
References
[1]. Miwa S, et al. Determination of serotonin turnover in the rat brain using 6-fluorotryptophan. J Neurochem. 1987 May;48(5):1577-80.
[2]. D Sugden, et al. Changes in the rat sleep-wake cycle produced by DL-6-fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase. Psychopharmacology (Berl). 1981;74(4):369-73.
Chemical & Physical Properties
Density
1.4±0.1 g/cm3
Boiling Point
450.7±45.0 °C at 760 mmHg
Melting Point
280-285 °C (dec.)(lit.)
Molecular Formula
C11H11FN2O2
Molecular Weight
222.216
Flash Point
226.4±28.7 °C
Exact Mass
222.080460
PSA
79.11000
LogP
1.09
Vapour Pressure
0.0±1.2 mmHg at 25°C
Index of Refraction
1.673
InChIKey
YMEXGEAJNZRQEH-UHFFFAOYSA-N
SMILES
NC(Cc1c[nH]c2cc(F)ccc12)C(=O)O
Storage condition
−20°C
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
YN6850000
CHEMICAL NAME :
DL-Tryptophan, 6-fluoro-
CAS REGISTRY NUMBER :
7730-20-3
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H11-F-N2-O2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 15,2134,1966
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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