CAS 18181-80-1|bromopropylate

Introduction：Basic information about CAS 18181-80-1|bromopropylate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. bromopropylate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles21
8. Synonyms

Common Name	bromopropylate
CAS Number	18181-80-1	Molecular Weight	428.115
Density	1.6±0.1 g/cm3	Boiling Point	504.5±45.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₆Br₂O₃	Melting Point	77ºC
MSDS	ChineseUSA	Flash Point	258.9±28.7 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	bromopropylate
Synonym	More Synonyms

bromopropylate BiologicalActivity

Description	Bromopropylate is a pesticide with moderate anti-androgenic activities[1].
Related Catalog	Research Areas >>EndocrinologySignaling Pathways >>Others >>Androgen Receptor
Target	Anti-androgenic[1]
References	[1]. Mengmeng Ma, et al. Combined Anti-Androgenic Effects of Mixtures of Agricultural Pesticides Using in Vitro and in Silico Methods. Ecotoxicol Environ Saf. 2019 Dec 30;186:109652.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	504.5±45.0 °C at 760 mmHg
Melting Point	77ºC
Molecular Formula	C₁₇H₁₆Br₂O₃
Molecular Weight	428.115
Flash Point	258.9±28.7 °C
Exact Mass	425.946594
PSA	46.53000
LogP	5.43
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.601
InChIKey	FOANIXZHAMJWOI-UHFFFAOYSA-N
SMILES	CC(C)OC(=O)C(O)(c1ccc(Br)cc1)c1ccc(Br)cc1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD2100000

CHEMICAL NAME :: Benzilic acid, 4,4'-dibromo-, isopropyl ester

CAS REGISTRY NUMBER :: 18181-80-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C17-H16-Br2-O3

MOLECULAR WEIGHT :: 428.15

WISWESSER LINE NOTATION :: ER DXQR DE&VOY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Morphological transformation

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 125 mg/kg

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 17,407,1996 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 56,107,1975

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R38
RIDADR	NONH for all modes of transport
RTECS	DD2100000
HS Code	2918199042

Customs

HS Code	2918199042

Articles21

Gas chromatographic determination of residues of bromopropylate and two of its degradation products in honey.

J. Assoc. Off. Anal. Chem. 67(5) , 896-901, (1984)

An analytical procedure is described for determination of residues of bromopropylate (BP) and its main degradation product 4,4'-dibromobenzophenone (BBP) in honey. The method also allows the determina...

Rapid multi-residue method for the determination of azinphos methyl, bromopropylate, chlorpyrifos, dimethoate, parathion methyl and phosalone in apricots and peaches by using negative chemical ionization ion trap technology.

J. Chromatogr. A. 996(1-2) , 181-7, (2003)

A rapid, selective and sensitive multi-residue method for the determination of six common pesticides in stone fruit samples is described. The proposed method involves the extraction of the pesticides ...

Promotion of altered hepatic foci development in rat liver, cytochrome P450 enzyme induction and inhibition of cell-cell communication by DDT and some structurally related organohalogen pesticides.

Carcinogenesis 11(8) , 1413-7, (1990)

The organochlorine pesticide 1,1'-(2,2,2-trichloroethylidene) bis(4-chlorobenzene) (DDT) and four structural analogues (bromopropylate, chlorobenzilate, dicofol and fenarimol) were investigated for th...

Synonyms

isopropyl 4,4’-dibromobenzilate

4-Bromo-α-(4-bromophenyl)-α-hydroxybenzeneacetic acid 1-methylethyl ester

Isopropyl bromobenzilate

Folbex VA

propan-2-yl bis(4-bromophenyl)hydroxyacetate

Caswell No. 511A

Benzilic acid, 4,4'-dibromo-, isopropyl ester (8CI)

isopropyl 4,4'-dibromobenzilate

Neoron

Benzeneacetic acid, 4-bromo-α-(4-bromophenyl)-α-hydroxy-, 1-methylethyl ester

Isopropyl-4,4'-dibrombenzilat

propan-2-yl bis(4-bromophenyl)(hydroxy)acetate

ACAROL

1-methylethyl 4-bromo-α-(4-bromophenyl)-α-hydroxybenzeneacetate

propan-2-yl 2,2-bis(4-bromophenyl)-2-hydroxyacetate

Phenisobromolate

EINECS 242-070-7

MFCD00078632

bromopropylate

isopropyl 2,2-bis(4-bromophenyl)-2-hydroxyacetate

4,4'-Dibrombenzilsaeure-isopropylester

4,4'-Dibromobenzilic acid isopropyl ester

Isopropyl bis(4-bromophenyl)(hydroxy)acetate

Ascarol 2E

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