Introduction：Basic information about CAS 74436-00-3|Geclosporin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Geclosporin |
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| CAS Number | 74436-00-3 | Molecular Weight | 1216.64000 |
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| Density | 1.013g/cm3 | Boiling Point | 1297.8ºC at 760 mmHg |
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| Molecular Formula | C63H113N11O12 | Melting Point | / |
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| MSDS | / | Flash Point | 738.7ºC |
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Names
| Name | Geclosporin |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Density | 1.013g/cm3 |
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| Boiling Point | 1297.8ºC at 760 mmHg |
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| Molecular Formula | C63H113N11O12 |
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| Molecular Weight | 1216.64000 |
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| Flash Point | 738.7ºC |
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| Exact Mass | 1215.86000 |
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| PSA | 278.80000 |
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| LogP | 4.53960 |
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| Index of Refraction | 1.467 |
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| InChIKey | ZMKGDQSIRSGUDJ-VSROPUKISA-N |
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| SMILES | CC=CCC(C)C(O)C1C(=O)NC(CCC)C(=O)N(C)CC(=O)N(C)C(CC(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(C(C)C)C(=O)N1C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- GZ4130000
- CHEMICAL NAME :
- Cyclosporin A, 7-L-norvaline-
- CAS REGISTRY NUMBER :
- 74436-00-3
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C63-H113-N11-O12
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 420 mg/kg/28D-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal - other changes
- REFERENCE :
- TRPLAU Transplantation. (Williams & Wilkins, Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1963- Volume(issue)/page/year: 57,1231,1994
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Synonyms
| Cyclo(((2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl) |
| cyclosporin G |
| (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Nva-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-) |
| Cyclosporin A,7-L-norvaline |
| Cyclosporin Impurity 7 |
