Introduction：Basic information about CAS 65089-17-0|Pirinixil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pirinixil |
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| CAS Number | 65089-17-0 | Molecular Weight | 366.86600 |
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| Density | 1.37g/cm3 | Boiling Point | 609.6ºC at 760 mmHg |
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| Molecular Formula | C16H19ClN4O2S | Melting Point | / |
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| MSDS | / | Flash Point | 322.5ºC |
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Names
| Name | 2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyl-N-(2-hydroxyethyl)acetamide |
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| Synonym | More Synonyms |
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Pirinixil BiologicalActivity
| Description | Pirinixil is a hypolipidemic agent of low toxicity. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| In Vivo | Pirinixil is a hypolipidemic agent of low toxicity. Total cholesterol is reduced by Pirinixi in the spleen, kidney and heart of rats. Pirinixil decreases the estimated total body cholesterol approximately 40%[1]. Pirinixil increases plasma cholesterol levels significantly without affecting plasma triglycerides. Liver cholesterol and triglycerides are markedly reduced by Pirinixil, while combined plasma and liver lipid levels decrease approximately 20%. Liver HMG-CoA reductase activity is not affected, but cholesterol 7α-hydroxylase is significantly reduced by Pirinixil[2]. |
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| Animal Admin | Male Sprague-Dawley rats, weighing 220 to 230 g at the start of each experiment, are used in all studies. They are kept in an air-conditioned environment, with controlled lighting and free access to water. Dietary treatments are (A) standard diet for rats and (B) 2% cholesterol+2% cholic acid regimen. Both diets are administered ad libitum, respectively for 1 and 2 weeks (standard diet) and for 2 weeks (cholesterolcholic acid diet). Groups of 5 rats in each of the 3 experiments (1 and 2 weeks with the standard diet, 2 weeks with the cholesterol-cholic acid diet) are administered Pirinixil daily in carboxymethylcellulose vehicle by gastric intubation, at the doses of 20 mg/kg. Controls are given a similar volume of vehicle daily by intubation[1]. |
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| References | [1]. D'Atri G, et al. Clofibrate, pirinixil (BR 931) and WY-14,643 do not affect body cholesterol in Sprague-Dawley rats. Atherosclerosis. 1980 Nov;37(3):475-83. [2]. Kritchevsky D, et al. Increased plasma cholesterol and decreased body lipid levels in Wistar rats following pirinixil(BR 931) treatment. Pharmacol Res Commun. 1979 Jun;11(6):475-82. |
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Chemical & Physical Properties
| Density | 1.37g/cm3 |
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| Boiling Point | 609.6ºC at 760 mmHg |
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| Molecular Formula | C16H19ClN4O2S |
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| Molecular Weight | 366.86600 |
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| Flash Point | 322.5ºC |
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| Exact Mass | 366.09200 |
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| PSA | 112.44000 |
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| LogP | 3.15490 |
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| Index of Refraction | 1.642 |
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| InChIKey | RZCKTPORLKUFGY-UHFFFAOYSA-N |
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| SMILES | Cc1cccc(Nc2cc(Cl)nc(SCC(=O)NCCO)n2)c1C |
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| Storage condition | 2-8℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- AB5860000
- CHEMICAL NAME :
- Acetamide, 2-((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)-N-( 2-hydroxyethyl)-
- CAS REGISTRY NUMBER :
- 65089-17-0
- BEILSTEIN REFERENCE NO. :
- 0845588
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C16-H19-Cl-N4-O2-S
- MOLECULAR WEIGHT :
- 366.90
- WISWESSER LINE NOTATION :
- T6M CN BHJ BS1VM2Q DG FMR B1 C1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1575 mg/kg/21D-C
- TOXIC EFFECTS :
- Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 17 gm/kg/81W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 137 gm/kg/81W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Cells - not otherwise specified
- DOSE/DURATION :
- 25 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,36,1980
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Synonyms
| 2-[4-chloro-6-(2,3-dimethyl-anilino)-pyrimidin-2-ylsulfanyl]-N-(2-hydroxy-ethyl)-acetamide |
| Pirinixil |
| BR-931 |
| <<4-chloro-6-<(2,3-dimethylphenyl)amino>-2-pyrimidinyl>thio>-N-(2-hydroxyethyl)acetamide |
| 2-((4-Chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)-N-(2-hydroxyethyl)acetamide |
| Pirinixilo [Spanish] |
| Pirinixilum [INN-Latin] |
| Pirinixilo [INN-Spanish] |
