Introduction：Basic information about CAS 64748-79-4|Azumolene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Azumolene |
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| CAS Number | 64748-79-4 | Molecular Weight | 349.14000 |
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| Density | 1.79g/cm3 | Boiling Point | / |
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| Molecular Formula | C13H9BrN4O3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-[[5-(4-bromophenyl)-1,3-oxazol-2-yl]methylideneamino]imidazolidine-2,4-dione |
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| Synonym | More Synonyms |
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Azumolene BiologicalActivity
| Description | Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research[1][2]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Metabolic Disease |
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| In Vitro | Pretreatment with 20 µM Azumolene for 1-2 min inhibits SOCE activated by subsequent addition of caffeine and ryanodine to promote RyR-dependent sarcoplasmic reticulum Ca2+ store depletion in mouse myotubes and adult muscle fibers[2]. |
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| In Vivo | The effect of Azumolene (EU4093) on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg/kg. This dose of Azumolene reduces the amplitude of the twitch to 31.9% of the control value. The contraction of intrafusal muscle as measured by the response of spindle afferent discharge is also reduced by Azumolene[1]. |
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| References | [1]. G C Leslie, et al. The effect of EU4093 (azumolene sodium) on the contraction of intrafusal muscle in the soleus muscle of the anaesthetized rat. Br J Pharmacol. 1989 Aug;97(4):1151-6. [2]. Viktor Yarotskyy, et al. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death. PLoS One. 2013 Oct 15;8(10):e77633. |
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Chemical & Physical Properties
| Density | 1.79g/cm3 |
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| Molecular Formula | C13H9BrN4O3 |
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| Molecular Weight | 349.14000 |
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| Exact Mass | 347.98600 |
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| PSA | 87.80000 |
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| LogP | 2.25650 |
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| Index of Refraction | 1.739 |
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| InChIKey | SEGCNGONCZQFDW-OMCISZLKSA-N |
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| SMILES | O=C1CN(N=Cc2ncc(-c3ccc(Br)cc3)o2)C(=O)N1 |
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Azumolenum |
| Azumolenum [Latin] |
| 1-[5-(4-bromo-phenyl)-oxazol-2-ylmethyleneamino]-imidazolidine-2,4-dione |
| Azumolene |
| Azumoleno |
| Azumolene [INN] |
| 1-(((5-(4-bromophenyl)-2-oxazolyl)methylene)amino)-2,4-imidazolidinedione |
| UNII-5U7IO9CV80 |
| Azumoleno [Spanish] |
