CAS 77-39-4|Cycrimine

Introduction：Basic information about CAS 77-39-4|Cycrimine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Cycrimine BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Cycrimine
CAS Number	77-39-4	Molecular Weight	287.44000
Density	1.057g/cm3	Boiling Point	433.5ºC at 760 mmHg
Molecular Formula	C₁₉H₂₉NO	Melting Point	/
MSDS	/	Flash Point	205.7ºC

Names

Name	cycrimine
Synonym	More Synonyms

Cycrimine BiologicalActivity

Description	Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder[1][2][3][4].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Neurological Disease
References	[1]. David T. CHAU. Methods of treating behaviorial and/or mental disorders. WO2014176460A1. [2]. Marzoughi S, et al. Tardive neurotoxicity of anticholinergic drugs: A review. J Neurochem. 2021 Sep;158(6):1334-1344. [3]. Tacke, et al. Syntheses and pharmacological characterization of achiral and chiral enantiopure C/Si/Ge-analogous derivatives of the muscarinic antagonist cycrimine: a study on C/Si/Ge bioisosterism. Journal of organometallic chemistry 640.1-2 (2001): 140-165. [4]. MAGEE KR, et al. Antispasmodic compound 08958 in treatment of paralysis agitans. J Am Med Assoc. 1953 Oct 24;153(8):715-8.

Description

Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder[1][2][3][4].

Related Catalog

Signaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Neurological Disease

References

[1]. David T. CHAU. Methods of treating behaviorial and/or mental disorders. WO2014176460A1.

[2]. Marzoughi S, et al. Tardive neurotoxicity of anticholinergic drugs: A review. J Neurochem. 2021 Sep;158(6):1334-1344.

[3]. Tacke, et al. Syntheses and pharmacological characterization of achiral and chiral enantiopure C/Si/Ge-analogous derivatives of the muscarinic antagonist cycrimine: a study on C/Si/Ge bioisosterism. Journal of organometallic chemistry 640.1-2 (2001): 140-165.

[4]. MAGEE KR, et al. Antispasmodic compound 08958 in treatment of paralysis agitans. J Am Med Assoc. 1953 Oct 24;153(8):715-8.

Chemical & Physical Properties

Density	1.057g/cm3
Boiling Point	433.5ºC at 760 mmHg
Molecular Formula	C₁₉H₂₉NO
Molecular Weight	287.44000
Flash Point	205.7ºC
Exact Mass	287.22500
PSA	23.47000
LogP	3.87830
Index of Refraction	1.554
InChIKey	SWRUZBWLEWHWRI-UHFFFAOYSA-N
SMILES	OC(CCN1CCCCC1)(c1ccccc1)C1CCCC1

Synonyms

Cycriminum [INN-Latin]

Cicrimina

1-cyclopentyl-1-phenyl-3-piperidin-1-yl-propan-1-ol

Cicrimina [INN-Spanish]

Cycriminum

1-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol

1-cyclopentyl-1-phenyl-3-piperidino-propan-1-ol

Pagitane

1-Cyclopentyl-1-phenyl-1-piperidino-propan-1-ol

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