Introduction：Basic information about CAS 66969-81-1|Tiodazosin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tiodazosin |
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| CAS Number | 66969-81-1 | Molecular Weight | 431.46900 |
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| Density | 1.5g/cm3 | Boiling Point | 690.2ºC at 760 mmHg |
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| Molecular Formula | C18H21N7O4S | Melting Point | / |
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| MSDS | / | Flash Point | 371.2ºC |
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Names
| Name | Tiodazosin |
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| Synonym | More Synonyms |
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Tiodazosin BiologicalActivity
| Description | Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease |
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| Target | alpha adrenergic receptor[1] |
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| In Vitro | Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. In the mesenteric artery, Tiodazosin produces a parallel shift to the right in the concentration response curves to norepinephrine. A Schild plot constructed from two concentrations of Tiodazosin results in a pA2 value of 8.66 and a slope equal to -0.99. Tiodazosin inhibits contraction to norepinephrine in the portal vein and the inhibition results in a nonparallel inhibition of the norepinephrine concentration-response curve with a marked depression of maximal norepinephrine response[1]. |
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| Cell Assay | Arteries and portal veins isolated male Wistar rats (150 to 300 g) are sued and prepared for in vitro studies. Vessels are incubated with appropriate concentrations of Tiodazosin, prazosin or phentolamine for one hour. Contractile responses to norepinephrine or potassium chloride are then repeated in the presence of Tiodazosin[1]. |
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| References | [1]. Cohen ML, et al. In vitro comparison of the pre- and postsynaptic alpha adrenergic receptor blocking properties of prazosin and tiodazosin (BL5111). |
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Chemical & Physical Properties
| Density | 1.5g/cm3 |
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| Boiling Point | 690.2ºC at 760 mmHg |
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| Molecular Formula | C18H21N7O4S |
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| Molecular Weight | 431.46900 |
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| Flash Point | 371.2ºC |
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| Exact Mass | 431.13800 |
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| PSA | 158.03000 |
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| LogP | 1.88060 |
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| Index of Refraction | 1.698 |
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| InChIKey | MULPYFRDYRZMDS-UHFFFAOYSA-N |
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| SMILES | COc1cc2nc(N3CCN(C(=O)c4nnc(SC)o4)CC3)nc(N)c2cc1OC |
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| Storage condition | 2-8℃ |
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Synonyms
| BL-5111 |
| 4-amino-6,7-dimethoxy-2-[4-(5-methylthio-1,3,4-oxadiazole-2-carbonyl]piperazin-1-yl)quinazoline |
| 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[[5-(methylthio)-1,3,4-oxadiazol-2-yl]carbonyl]piperazine |
