CAS 103926-64-3|Sepimostat

Introduction：Basic information about CAS 103926-64-3|Sepimostat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sepimostat BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Sepimostat
CAS Number	103926-64-3	Molecular Weight	373.40800
Density	1.39g/cm3	Boiling Point	607.4ºC at 760mmHg
Molecular Formula	C₂₁H₁₉N₅O₂	Melting Point	/
MSDS	/	Flash Point	321.2ºC

Names

Name	(6-carbamimidoylnaphthalen-2-yl) 4-(4,5-dihydro-1H-imidazol-2-ylamino)benzoate
Synonym	More Synonyms

Sepimostat BiologicalActivity

Description	Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7 µM[1].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR
In Vivo	Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect[1]. Animal Model: Male Sprague Dawley rats weighing 150-300 g[1]. Dosage: Intravitreal injection. Administration: 1 to 100 nmol/eye. Result: Exhibited neuroprotective effects significantly.
References	[1]. Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.

Chemical & Physical Properties

Density	1.39g/cm3
Boiling Point	607.4ºC at 760mmHg
Molecular Formula	C₂₁H₁₉N₅O₂
Molecular Weight	373.40800
Flash Point	321.2ºC
Exact Mass	373.15400
PSA	112.59000
LogP	3.35160
Vapour Pressure	1.06E-14mmHg at 25°C
Index of Refraction	1.707
InChIKey	QMRJOIUGPCVZPH-UHFFFAOYSA-N
SMILES	N=C(N)c1ccc2cc(OC(=O)c3ccc(NC4=NCCN4)cc3)ccc2c1

Synonyms

UNII-5ZFR16F4QQ

Sepimostat [INN]

Sepimostat

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