CAS 1839-18-5|2-chloroadenine
| Common Name | 2-chloroadenine | ||
|---|---|---|---|
| CAS Number | 1839-18-5 | Molecular Weight | 169.57 |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 485.5±27.0 °C at 760 mmHg |
| Molecular Formula | C5H4ClN5 | Melting Point | >300°C(dec) |
| MSDS | USA | Flash Point | 247.4±23.7 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-Chloroadenine |
|---|---|
| Synonym | More Synonyms |
2-chloroadenine BiologicalActivity
| Description | 2-Chloroadenine (6-Amino-2-chloropurine) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | 2-Chloroadenine 是一种杂环构建块，已被用于合成具有抗肿瘤活性的腺苷抗代谢产物。它也是 2-氯-2'-脱氧腺苷的主要分解产物。 |
| References | [1]. Bauta, WE, Schulmeier, BE, Bur the , BJ, et al.A new process for antineoplastic agent clofarabineOrg. Proc. Res. Dev.8(6)889-896(2004) [2]. Bontemps, F., Delacauw, A., Cardoen, S., et al. Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-29-deoxyadenosine Biochem. Pharmacol.59(10)1237-1243(2000) |
Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 485.5±27.0 °C at 760 mmHg |
| Melting Point | >300°C(dec) |
| Molecular Formula | C5H4ClN5 |
| Molecular Weight | 169.57 |
| Flash Point | 247.4±23.7 °C |
| Exact Mass | 169.015518 |
| PSA | 80.48000 |
| LogP | 0.35 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.827 |
| InChIKey | HBJGQJWNMZDFKL-UHFFFAOYSA-N |
| SMILES | Nc1nc(Cl)nc2nc[nH]c12 |
| Storage condition | -20°C Freezer |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Hazard Codes | Xi |
| Risk Phrases | 22 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles14
More Articles| Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia. Cancer Lett. 210(2) , 171-7, (2004) The nucleoside analog 2-chlorodeoxyadenosine (Cladribine, CdA) is used in the treatment of patients with several hematological malignancies. After administration of CdA, the major catabolite measured ... | |
| [Synthesis of 2-chloro-2'-deoxyadenosine by microbiological transglycosylation using a recombinant Escherichia coli strain]. Prikl. Biokhim. Mikrobiol. 44(2) , 181-6, (2008) Cladribine (2-chloro-2'-deoxyadenosine) was synthesized using intact cells of the recombinant Escherichia coli strain producing Geobacillus stearothermophilus B-2194 thermostable purine-nucleoside pho... | |
| Age-related changes in ischemic tolerance in male and female mouse hearts. J. Mol. Cell. Cardiol. 38(2) , 245-56, (2005) Aging is associated with reduced tolerance to ischemic insult, and genesis of this intolerant phenotype is poorly understood. We characterized effects of aging and gender on cardiovascular function an... |
Synonyms
| CHLOROADENINE |
| 2-chlor-9h-purin-6-amin |
| 7H-Purin-6-amine, 2-chloro- |
| 6-amino-2-chloro-9H-purine |
| 2-chloro-7h-purin-6-amine |
| 6-amino-2-chloropurine |
| 6-Amino-2-chloro-7H-purine |
| MFCD00127773 |
| 2-Chloro-1H-purin-6-amine |
| 2-Chloroadenine |
| 2-CHLORO-6-AMINOPURINE |
| 9H-purin-6-amine, 2-chloro- |
| 2-chloropurin-6-amine |
| 2-Chlorophenthiazine |
| 2-chloro-9H-purin-6-amine |
| Purine, 6-amino-2-chloro- |
