CAS 78-98-8|Methylglyoxal

Introduction：Basic information about CAS 78-98-8|Methylglyoxal, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Methylglyoxal BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles122
8. Synonyms

Common Name	Methylglyoxal
CAS Number	78-98-8	Molecular Weight	72.063
Density	1.0±0.1 g/cm3	Boiling Point	72.0±0.0 °C at 760 mmHg
Molecular Formula	C₃H₄O₂	Melting Point	25 °C
MSDS	ChineseUSA	Flash Point	2.5±4.4 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	methylglyoxal
Synonym	More Synonyms

Methylglyoxal BiologicalActivity

Description	Pyruvic aldehyde is often used as a reagent in organic synthesis, as a flavoring agent, and in tanning.
Related Catalog	Research Areas >>OthersNatural Products >>Others
Target	Human Endogenous Metabolite

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	72.0±0.0 °C at 760 mmHg
Melting Point	25 °C
Molecular Formula	C₃H₄O₂
Molecular Weight	72.063
Flash Point	2.5±4.4 °C
Exact Mass	72.021126
PSA	34.14000
LogP	-0.80
Vapour Pressure	120.9±0.1 mmHg at 25°C
Index of Refraction	1.364
InChIKey	AIJULSRZWUXGPQ-UHFFFAOYSA-N
SMILES	CC(=O)C=O
Storage condition	2-8°C
Water Solubility	>=10 g/100 mL at 17 ºC

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UZ0700000

CHEMICAL NAME :: Pyruvaldehyde

CAS REGISTRY NUMBER :: 78-98-8

BEILSTEIN REFERENCE NO. :: 0906750

LAST UPDATED :: 199701

DATA ITEMS CITED :: 31

MOLECULAR FORMULA :: C3-H4-O2

MOLECULAR WEIGHT :: 72.07

WISWESSER LINE NOTATION :: VHV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 179 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 252 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - guinea pig Cells - not otherwise specified

DOSE/DURATION :: 6600 umol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 38,339,1982 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 51,443,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 51,443,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 51,443,1991

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	-
HS Code	2914400090

Customs

HS Code	2914400090
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles122

Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new three-domain family of bacterial flavoproteins.

Biochem. J. 464(3) , 387-99, (2014)

The aaoSo gene from Streptococcus oligofermentans encodes a 43 kDa flavoprotein, aminoacetone oxidase (SoAAO), which was reported to possess a low catalytic activity against several different L-amino ...

The Chilean wild raspberry (Rubus geoides Sm.) increases intracellular GSH content and protects against H2O2 and methylglyoxal-induced damage in AGS cells.

Food Chem. 194 , 908-19, (2015)

The Chilean raspberry Rubus geoides Sm. (Rosaceae) is a native species occurring in the Patagonia. Five R. geoides samples were assessed for phenolic content and composition, antioxidant activity, eff...

Novel HPLC--Fluorescence methodology for the determination of methylglyoxal and glyoxal. Application to the analysis of monovarietal wines "Ribera del Guadiana".

Food Chem. 187 , 159-65, (2015)

The determination and quantification of α-dicarbonyl compounds, glyoxal and methylglyoxal, in "Ribera del Guadiana" monovarietal wines (Extremadura, Spain) without sample clean-up has been carried out...

Synonyms

2-oxo-propanal

2-oxo-Propionaldehyde

methyl-glyoxal

α-Ketopropionaldehyde

acetylformaldehyde

2-keto Propionaldehyde

Pyruvaldehyde (8CI)

Ketopropionaldehyde

2-Oxopropanal

MFCD00006960

Methylglyoxal

Pyruvic aldehyde

Propanal, 2-oxo-

pyruvaldehyde

EINECS 201-164-8

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