CAS 1867-73-8|N6-Methyladenosine

Introduction：Basic information about CAS 1867-73-8|N6-Methyladenosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameN6-Methyladenosine
CAS Number1867-73-8Molecular Weight281.26800
Density1.85g/cm3Boiling Point649.1ºC at 760mmHg
Molecular FormulaC11H15N5O4Melting Point/
MSDS/Flash Point346.3ºC

Names

NameN6-methyladenosine
SynonymMore Synonyms

N6-Methyladenosine BiologicalActivity

DescriptionN6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes.
Related CatalogSignaling Pathways >>Others >>OthersNatural Products >>AlkaloidResearch Areas >>Others
In VitroN6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion[1]. N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits[2].
References

[1]. Wang X, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20.

[2]. Li Y, et al. Genome-wide detection of high abundance N6-methyladenosine sites by microarray. RNA. 2015 Aug;21(8):1511-8.

Chemical & Physical Properties

Density1.85g/cm3
Boiling Point649.1ºC at 760mmHg
Molecular FormulaC11H15N5O4
Molecular Weight281.26800
Flash Point346.3ºC
Exact Mass281.11200
PSA125.55000
Vapour Pressure9.86E-18mmHg at 25°C
Index of Refraction1.814
InChIKeyVQAYFKKCNSOZKM-IOSLPCCCSA-N
SMILESCNc1ncnc2c1ncn2C1OC(CO)C(O)C1O
Storage condition2-8°C

Safety Information

Hazard CodesXi
HS Code2934999090

Customs

HS Code2934999090
Summary2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

N-Methyladenosine
6-methylaminopurine riboside
N(6)-methyladenosine
Adenosine,N-methyl
6-N-Methyladenoside
n6-methyladenosine
6-Methylaminopurine D-riboside
6-METHYLAMINOPURINE 9-RIBOFURANOSIDE
6-Methylaminopurine ribonucleoside
6-Methylaminopurinosine
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