Introduction：Basic information about CAS 658-48-0|a-methyl-D-tyrosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
α-Methyl-p-tyrosine is a competitive inhibitor of the enzyme tyrosine hydroxylase, which converts tyrosine to Levodopa (DOPA). α-Methyl-p-tyrosine is an orally active inhibitor of catecholamine synthesis which inhibits the hydroxylation of tyrosine to DOPA[1].
Related Catalog
Research Areas >>CancerSignaling Pathways >>Others >>Others
References
[1]. R N Brogden, et al. alpha-Methyl-p-tyrosine: a review of its pharmacology and clinical use. Drugs. 1981 Feb;21(2):81-9.
Chemical & Physical Properties
Density
1.3±0.1 g/cm3
Boiling Point
383.7±32.0 °C at 760 mmHg
Melting Point
>300ºC(lit.)
Molecular Formula
C10H13NO3
Molecular Weight
195.215
Flash Point
185.9±25.1 °C
Exact Mass
195.089539
PSA
83.55000
LogP
0.73
Vapour Pressure
0.0±0.9 mmHg at 25°C
Index of Refraction
1.600
InChIKey
NHTGHBARYWONDQ-UHFFFAOYSA-N
SMILES
CC(N)(Cc1ccc(O)cc1)C(=O)O
Storage condition
−20°C
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
YP2890000
CHEMICAL NAME :
Tyrosine, alpha-methyl-
CAS REGISTRY NUMBER :
658-48-0
BEILSTEIN REFERENCE NO. :
2938704
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H13-N-O3
MOLECULAR WEIGHT :
195.24
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28 gm/kg/4W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 28,435,1970
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles45
More Articles
Contribution of dopamine to mitochondrial complex I inhibition and dopaminergic deficits caused by methylenedioxymethamphetamine in mice.
Neuropharmacology 93 , 124-33, (2015)
Methylenedioxymethamphetamine (MDMA) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. Current evidence indicates that MDMA-induced neurotoxicity is mediated by oxi...
Monoamine receptor agonists, acting preferentially at presynaptic autoreceptors and heteroreceptors, downregulate the cell fate adaptor FADD in rat brain cortex.
Neuropharmacology 89 , 204-14, (2014)
FADD is a crucial adaptor of death receptors that can engage apoptosis or survival actions (e.g. neuroplasticity) through its phosphorylated form (p-FADD). Although FADD was shown to participate in re...
Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice.
Endocrinology 156 , 2470-81, (2015)
Fibroblast growth factor 21 (FGF21) has multiple metabolic actions, including the induction of browning in white adipose tissue. Although FGF21 stimulated browning results from a direct interaction be...
