CAS 343351-67-7|NSC697923
Introduction：Basic information about CAS 343351-67-7|NSC697923, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NSC697923 | ||
|---|---|---|---|
| CAS Number | 343351-67-7 | Molecular Weight | 267.25800 |
| Density | / | Boiling Point | / |
| Molecular Formula | C11H9NO5S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS05, GHS07 | Signal Word | Danger |
Names
| Name | 2-[(4-Methylphenyl)sulfonyl]-5-nitrofur |
|---|---|
| Synonym | More Synonyms |
NSC697923 BiologicalActivity
| Description | NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>E1/E2/E3 Enzyme |
| In Vitro | NSC697923 (0-5 μM; 24 hours) shows cytotoxic effect on NB cell lines[1]. NSC697923 (3 μM; 2 hours) can also induce apoptosis in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway[1]. NSC697923 induces apoptosis in p53 wild-type NB cell lines by promoting p53 nuclear translocation and activation[1]. Cell Viability Assay[1] Cell Line: Three MYCN-amplified cell lines: IMR32, NGP, NB19 and three MYCN-non-amplified cell lines: CHLA-255, SK-N-AS, and SH-SY5Y Concentration: 0-5 μM Incubation Time: 24 hours Result: Significantly reduced NB cells viability in a dose-dependent manner. Also induced cell death in the p53 non-functional cell line SK-N-AS and p53 partially functional cell line NB-19. Western Blot Analysis[1] Cell Line: p53 wild-type SH-SY5Y and IMR32 cells Concentration: 3 μM Incubation Time: 2 hours Result: Induced expression of p53-targeted gene p21 as well as the cleavage of caspase 3 in two p53 wild-type cell lines SH-SY5Y and IMR32. |
| In Vivo | NSC697923 (5 mg/kg; i.p.; daily for 10 days) suppresses NB tumor growth in SH-SY5Y and NGP xenografts[1]. Animal Model: 5- to 6-week-old female athymic Ncr nude mice (orthotopic mouse model of NB; SH-SY5Y and NGP xenografts)[1] Dosage: 5 mg/kg Administration: I.p.; daily for 10 days Result: Significant tumor regression in both SH-SY5Y and NGP xenografts. |
| References | [1]. Cheng J, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5(2):e1079. Published 2014 Feb 20. [2]. Hodge CD, et al. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. ACS Chem Biol. 2015;10(7):1718-1728. |
Chemical & Physical Properties
| Molecular Formula | C11H9NO5S |
|---|---|
| Molecular Weight | 267.25800 |
| Exact Mass | 267.02000 |
| PSA | 101.48000 |
| LogP | 3.93300 |
| Appearance of Characters | white to beige |
| InChIKey | GAUHIPWCDXOLCZ-UHFFFAOYSA-N |
| SMILES | Cc1ccc(S(=O)(=O)c2ccc([N+](=O)[O-])o2)cc1 |
| Storage condition | ?20°C |
| Water Solubility | DMSO: soluble20mg/mL, clear |
Safety Information
| Symbol | GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H318 |
| Precautionary Statements | P280-P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Phrases | 22-41 |
| Safety Phrases | 26-39 |
| RIDADR | NONH for all modes of transport |
Articles1
More Articles| Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. ACS Chem. Biol. 10(7) , 1718-28, (2015) Ubc13 is an E2 ubiquitin conjugating enzyme that functions in nuclear DNA damage signaling and cytoplasmic NF-κB signaling. Here, we present the structures of complexes of Ubc13 with two inhibitors, N... |
Synonyms
| NSC 697923 |
| NSC697923 |
