CAS 491871-58-0|TCS PIM-1 1

Introduction：Basic information about CAS 491871-58-0|TCS PIM-1 1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. TCS PIM-1 1 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	TCS PIM-1 1
CAS Number	491871-58-0	Molecular Weight	367.196
Density	1.6±0.1 g/cm3	Boiling Point	592.6±50.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₁BrN₂O₂	Melting Point	/
MSDS	/	Flash Point	312.2±30.1 °C

Names

Name	6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydro-3-pyridine carbonitrile
Synonym	More Synonyms

TCS PIM-1 1 BiologicalActivity

Description	TCS PIM-1 1(sc-204330) is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).IC50 value: 50 nM [1]Target: Pim-1TCS PIM-1 1 bound convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggested that 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2 (IC50 > 20 lM). Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors.
Related Catalog	Signaling Pathways >>JAK/STAT Signaling >>PimResearch Areas >>Cancer
References	[1]. Cheney IW, et al. Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1679-83. [2]. Shen Y, et al. Pim-1 inhibitor attenuates trinitrobenzene sulphonic acid induced colitis in the mice. Clin Res Hepatol Gastroenterol. 2018 Sep;42(4):382-386.

Description

TCS PIM-1 1(sc-204330) is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).IC50 value: 50 nM [1]Target: Pim-1TCS PIM-1 1 bound convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggested that 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2 (IC50 > 20 lM). Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors.

Related Catalog

Signaling Pathways >>JAK/STAT Signaling >>PimResearch Areas >>Cancer

References

[1]. Cheney IW, et al. Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1679-83.

[2]. Shen Y, et al. Pim-1 inhibitor attenuates trinitrobenzene sulphonic acid induced colitis in the mice. Clin Res Hepatol Gastroenterol. 2018 Sep;42(4):382-386.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	592.6±50.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₁BrN₂O₂
Molecular Weight	367.196
Flash Point	312.2±30.1 °C
Exact Mass	366.000397
PSA	77.14000
LogP	4.60
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.728
InChIKey	SVSYJTYGPLVUOZ-UHFFFAOYSA-N
SMILES	N#Cc1c(-c2ccccc2)cc(-c2cc(Br)ccc2O)[nH]c1=O
Storage condition	2-8℃

Synonyms

2-oxo-4-phenyl-5H-furan-3-carbonitrile

6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

TCS PIM-1 1

3-cyano-4-phenyl-2(5H)-furanone

3-Cyano-4-phenyl-2(5H)-furanon

3-Cyan-4-phenyl-2(5H)-furanon

2-oxo-4-phenyl-2,5-dihydro-furan-3-carbonitrile

2-oxo-4-phenyl-2,5-dihydro-3-furancarbonitrile

3-Pyridinecarbonitrile, 6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-

3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone

3-cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone

6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydro-3-pyridinecarbonitrile

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