CAS 638156-11-3|CID-2011756
Introduction：Basic information about CAS 638156-11-3|CID-2011756, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | CID-2011756 | ||
|---|---|---|---|
| CAS Number | 638156-11-3 | Molecular Weight | 396.867 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 491.0±45.0 °C at 760 mmHg |
| Molecular Formula | C22H21ClN2O3 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 250.8±28.7 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 5-(3-chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide |
|---|---|
| Synonym | More Synonyms |
CID-2011756 BiologicalActivity
| Description | CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>PKDResearch Areas >>Cancer |
| Target | Cellular PKD2:0.6 μM (IC50) Cellular PKD3:0.7 μM (IC50) PKD1:3.2 μM (IC50) |
| In Vitro | CID 2011756 is an ATP-competitive PKD1 inhibitor, with an IC50 of 3.2 µM. CID 2011756 decreases the phosphorylation of endogenous PKD1 Ser916 in LNCaP cancer cells with an EC50 of 10±0.7 µM. CID 2011756 also has cellular pan-PKD inhibitory effects, with IC50s of 0.6±0.1 µM and 0.7±0.2 µM for PKD2 and PKD3, respectively[1]. |
| References | [1]. Sharlow ER, et al. Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. PLoS One. 2011;6(10):e25134. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 491.0±45.0 °C at 760 mmHg |
| Molecular Formula | C22H21ClN2O3 |
| Molecular Weight | 396.867 |
| Flash Point | 250.8±28.7 °C |
| Exact Mass | 396.124084 |
| PSA | 58.20000 |
| LogP | 3.69 |
| Appearance of Characters | white solid |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.633 |
| Storage condition | -20℃ |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
Synonyms
| QCR-12 |
| 5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-2-furamide |
| HMS2426M13 |
| 2-Furancarboxamide, 5-(3-chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]- |
| cc-693 |
| CID-2011756 |
| CID 2011756 |
