Introduction：Basic information about CAS 492445-28-0|PHA690509, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PHA690509 |
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| CAS Number | 492445-28-0 | Molecular Weight | 331.432 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C17H21N3O2S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | (2S)-2-(4-Acetamidophenyl)-N-(5-isopropyl-1,3-thiazol-2-yl)propan amide |
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| Synonym | More Synonyms |
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PHA690509 BiologicalActivity
| Description | PHA-690509 is an anti-ZikV compound that inhibits ZikV replication. PHA-690509 is also a CDK inhibitor, and inhibits caspase-3 activity[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Apoptosis >>CaspaseSignaling Pathways >>Cell Cycle/DNA Damage >>CDK |
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| References | [1]. Devillers J. Repurposing drugs for use against Zika virus infection. SAR QSAR Environ Res. 2018 Feb;29(2):103-115. [2]. Alam A, et al. Recent trends in ZikV research: A step away from cure. Biomed Pharmacother. 2017 Jul;91:1152-1159. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Molecular Formula | C17H21N3O2S |
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| Molecular Weight | 331.432 |
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| Exact Mass | 331.135437 |
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| PSA | 106.31000 |
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| LogP | 3.09 |
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| Index of Refraction | 1.629 |
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| InChIKey | NFSKEXQRNDSSAN-NSHDSACASA-N |
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| SMILES | CC(=O)Nc1ccc(C(C)C(=O)Nc2ncc(C(C)C)s2)cc1 |
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Synonyms
| (2S)-2-(4-Acetamidophenyl)-N-(5-isopropyl-1,3-thiazol-2-yl)propanamide |
| (2S)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno-[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methylpropanamide |
| NOP-1A |
| (2S)-2-[4-(acetylamino)phenyl]-N-(5-isopropyl-1,3-thiazol-2-yl)propanamide |
| Benzeneacetamide, 4-(acetylamino)-α-methyl-N-[5-(1-methylethyl)-2-thiazolyl]-, (αS)- |
| (2S)-2-[(3,6-diethylpyrazin-2-yl)amino]butan-1-ol |
