Introduction：Basic information about CAS 3465-72-3|trans-Urocanic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | trans-Urocanic acid |
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| CAS Number | 3465-72-3 | Molecular Weight | 138.124 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 456.9±20.0 °C at 760 mmHg |
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| Molecular Formula | C6H6N2O2 | Melting Point | / |
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| MSDS | / | Flash Point | 230.1±21.8 °C |
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Names
| Name | (2E)-3-(1H-Imidazol-4-yl)acrylic acid |
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| Synonym | More Synonyms |
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trans-Urocanic acid BiologicalActivity
| Description | trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function[1]. |
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| Related Catalog | Research Areas >>Inflammation/Immunology |
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| Target | Human Endogenous Metabolite |
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| In Vitro | trans-urocanic acid (trans-UCA) partially inhibits cytotoxic function of IL-2-activated NK cells and reduces IL-2-induced activation of NK cells[1]. trans-urocanic acid (trans-UCA;100 μg/mL) slightly decreases cell proliferation and viability of primary human keratinocytes[2]. Cell Proliferation Assay[2] Cell Line: Primary human keratinocytes Concentration: 100 μg/mL Incubation Time: 24 hours Result: Decreased cell proliferation and viability. |
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| References | [1]. J Uksila, et al. Trans-urocanic acid, a natural epidermal constituent, inhibits human natural killer cell activity in vitro. Exp Dermatol. 1994 Apr;3(2):61-5. [2]. Kazuyo Kaneko, et al. cis-Urocanic acid enhances prostaglandin E2 release and apoptotic cell death via reactive oxygen species in human keratinocytes. J Invest Dermatol. 2011 Jun;131(6):1262-71. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 456.9±20.0 °C at 760 mmHg |
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| Molecular Formula | C6H6N2O2 |
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| Molecular Weight | 138.124 |
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| Flash Point | 230.1±21.8 °C |
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| Exact Mass | 138.042923 |
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| PSA | 65.98000 |
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| LogP | 0.01 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.674 |
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| InChIKey | LOIYMIARKYCTBW-OWOJBTEDSA-N |
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| SMILES | O=C(O)C=Cc1cnc[nH]1 |
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| Storage condition | 2-8C |
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Safety Information
Customs
| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-Propenoic acid, 3-(1H-imidazol-4-yl)-, (2E)- |
| Trans-Urocanic acid |
| (E)-3-(1H-Imidazol-5-yl)-2-propenoic acid |
| (E)-urocanic acid |
| E-3-(imidazol-4-yl)propenoic acid |
| (2E)-3-(1H-Imidazol-4-yl)acrylic acid |
| (Z)-4-pyridalacetophenone |
| trans-4-imidazoleacrylic acid |
| (2E)-3-(1H-imidazol-4-yl)prop-2-enoic acid |
| (E)-3-(1H-imidazol-4-yl)acrylic acid |
| 1-phenyl-3-(4-pyridinyl)-2-propen-1-one |
| Urocanic acid |
| 2-propenoic acid, 3-(1H-imidazol-5-yl)-, (2E)- |
| 3-(1H-imidazol-4-yl)prop-2-enoic acid |
| (E)-3-(1H-imidazol-4-yl)-2-propenoic acid |
| Urocanate |
| (E)-3-(imidazol-4-yl)acrylic acid |
| E-3-(4-Pyridyl)-1-phenylprop-2-en-1-on |
| 4-Imidazoleacrylic Acid |
| (2E)-3-(1H-Imidazol-5-yl)acrylic acid |
