Introduction：Basic information about CAS 109683-61-6|Utibapril, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Utibapril |
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| CAS Number | 109683-61-6 | Molecular Weight | 449.56400 |
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| Density | 1.24g/cm3 | Boiling Point | 597.5ºC at 760 mmHg |
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| Molecular Formula | C22H31N3O5S | Melting Point | / |
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| MSDS | / | Flash Point | 315.2ºC |
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Names
| Name | 5-tert-butyl-3-[2-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]propanoyl]-2H-1,3,4-thiadiazole-2-carboxylic acid |
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| Synonym | More Synonyms |
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Utibapril BiologicalActivity
| Description | Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Angiotensin-converting Enzyme (ACE)Research Areas >>Cardiovascular Disease |
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| In Vivo | Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. Utibapril (2 μg/kg/day) significantly inhibits vascular ACE activity, and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE. Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited after treatment with the higher doses of utibapril[1]. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts[2]. |
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| References | [1]. Buikema H, et al. Differential inhibition of plasma versus tissue ACE by utibapril: biochemical and functional evidence for inhibition of vascular ACE activity. J Cardiovasc Pharmacol. 1997 May;29(5):684-91. [2]. Carr RD, et al. Preferential biliary elimination of FPL 63547, a novel inhibitor of angiotensin-converting enzyme, in the rat. Br J Pharmacol. 1990 May;100(1):90-4. |
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Chemical & Physical Properties
| Density | 1.24g/cm3 |
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| Boiling Point | 597.5ºC at 760 mmHg |
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| Molecular Formula | C22H31N3O5S |
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| Molecular Weight | 449.56400 |
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| Flash Point | 315.2ºC |
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| Exact Mass | 449.19800 |
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| PSA | 133.60000 |
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| LogP | 2.63910 |
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| Vapour Pressure | 3.98E-15mmHg at 25°C |
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| Index of Refraction | 1.586 |
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| InChIKey | FTYVYAGWBXTWTN-ZVZYQTTQSA-N |
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| SMILES | CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1N=C(C(C)(C)C)SC1C(=O)O |
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| Storage condition | 2-8℃ |
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Synonyms
| Utibaprilo |
| Utibaprilo [INN-Spanish] |
| 5-tert-butyl-3-[n-(1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl]-2,3-dihydro-1,3,4-thiadiazole-2-carboxylic acid |
| Utibapril |
| Utibaprilum [INN-Latin] |
| Utibaprilum |
| 5-tert-butyl-3-{N-[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl}-2,3-dihydro-1,3,4-thiadiazole-2(S)-carboxylic acid |
