CAS 186268-78-0|GPI-1485

Introduction：Basic information about CAS 186268-78-0|GPI-1485, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameGPI-1485
CAS Number186268-78-0Molecular Weight241.28400
Density1.189 g/cm3Boiling Point386.198ºC at 760 mmHg
Molecular FormulaC12H19NO4Melting Point/
MSDS/Flash Point187.366ºC

Names

Name(2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylic acid
SynonymMore Synonyms

GPI-1485 BiologicalActivity

DescriptionGPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke[1].
Related CatalogSignaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
In VitroGPI-1485 (GM1485; 100 μM) induces cellular reprogramming and neural cell induction in normal human dermal fibroblasts (NHDF)[1]. Cell Viability Assay[1] Cell Line: Normal human dermal fibroblasts (NHDF)[1] Concentration: 100 μM Incubation Time: Result: Induced cellular reprogramming and neural cell induction.
In VivoGPI-1485 (GM1485; 5 mg/kg; intraperitoneal injection; 6-week period of daily) improves long-term neurological recovery in rats[1]. Animal Model: Adult male Wistar rats, weighing 250-300 g[1] Dosage: 5 mg/kg Administration: Intraperitoneal injection; daily; for a total of 42 days Result: Administration improved neurological function and is consistent with an upregulation of endogenous neurogenesis following stroke in rats.
References

[1]. Andrew F Ducruet , et al. GM1485, a Nonimmunosuppressive Immunophilin Ligand, Promotes Neurofunctional Improvement and Neural Regeneration Following Stroke. J Neurosci Res. 2012 Jul;90(7):1413-23.

Chemical & Physical Properties

Density1.189 g/cm3
Boiling Point386.198ºC at 760 mmHg
Molecular FormulaC12H19NO4
Molecular Weight241.28400
Flash Point187.366ºC
Exact Mass241.13100
PSA74.68000
LogP1.00520
InChIKeyFOPALECPEUVCTL-QMMMGPOBSA-N
SMILESCCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)O

Safety Information

Hazard CodesXi
HS Code2933990090

Customs

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

(S)-methyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate
UNII-0709BVY57W
(2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidincarboxylic acid
GPI-1485
(2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-pyrrolidine-carboxylic acid
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