Introduction：Basic information about CAS 18711-15-4|4,6-Dichloroisatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4,6-Dichloroisatin |
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| CAS Number | 18711-15-4 | Molecular Weight | 216.02 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C8H3Cl2NO2 | Melting Point | 260.5-261°C |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4,6-dichloro-1h-indole-2,3-dione |
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| Synonym | More Synonyms |
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4,6-Dichloroisatin BiologicalActivity
| Description | CFL-120 is a potent KRasG12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>GPCR/G Protein >>Ras |
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| Target | KRAS(G12C) |
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| In Vitro | CFL-120 (72 h) 显示出抗增殖作用，对 H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, CCD-986Sk 细胞的 IC50 值分别为 111.0, 23.6, 13.7, 16.9, 44.4, 14.8, 38.0, 30.0, 13.1, 9.8, 47.9, 24.4, 42.7 µM[1]。 |
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| In Vivo | CFL-120 (5 mg/kg，5 次治疗；15 mg/kg，5 次治疗；30 mg/kg，3 次治疗；i.p.) 减少皮下人肺癌 H1792 (KRasG12C 突变体) 和 LCLC-103H (KRasWT) 小鼠肿瘤模型的生长[1]。 Animal Model: NOD/SCID female mice (KRasWT (LCLC-103H) or KRasG12C (H1792) tumors)[1] Dosage: 5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments Administration: I.p. Result: Reduced tumor growth compared to the control group in KRasG12C mutated model for 35.8%. |
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| References | [1]. Orgován Z, et al. Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency. Eur J Med Chem. 2023 Mar 15;250:115212. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Melting Point | 260.5-261°C |
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| Molecular Formula | C8H3Cl2NO2 |
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| Molecular Weight | 216.02 |
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| Exact Mass | 214.954086 |
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| PSA | 46.17000 |
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| LogP | 2.20 |
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| Index of Refraction | 1.638 |
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| InChIKey | CGCVHJCZBIYRQC-UHFFFAOYSA-N |
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| SMILES | O=C1Nc2cc(Cl)cc(Cl)c2C1=O |
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Safety Information
| Hazard Codes | T+ |
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| RIDADR | 2811.0 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 4,6-dichloro-2,3-dihydro-1H-indole-2,3-dione |
| 1H-indole-2,3-dione, 4,6-dichloro- |
| 4,6-dichloroisatine |
| 4,6-DICHLORO-1H-INDOLE-2,3-DIONE |
| 4,6-dichloroindolin-2,3-dione |
| 4,6-Dichlor-indolin-2,3-dion |
| 4,6-dichloroisatin |
| 4,6-dichloro-indoline-2,3-dione |
