CAS 898537-18-3|Luseogliflozin

Introduction：Basic information about CAS 898537-18-3|Luseogliflozin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Luseogliflozin BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Luseogliflozin
CAS Number	898537-18-3	Molecular Weight	434.546
Density	1.3±0.1 g/cm3	Boiling Point	624.5±55.0 °C at 760 mmHg
Molecular Formula	C₂₃H₃₀O₆S	Melting Point	155.0-157.0℃
MSDS	/	Flash Point	331.5±31.5 °C

Names

Name	(2S,3R,4R,5S,6R)-2-[5-[(4-ethoxyphenyl)methyl]-2-methoxy-4-methylphenyl]-6-(hydroxymethyl)thiane-3,4,5-triol
Synonym	More Synonyms

Luseogliflozin BiologicalActivity

Description	Luseogliflozin (TS 071) is a potent, selective, orally active sodium-dependent glucose cotransporter (SGLT) 2 inhibitor, with an IC50 of 2.26 nM, about 1765-fold selectivity over SGLT1 (IC50, 3990 nM). Luseogliflozin has the protential for treating type 2 diabetes.
Related Catalog	Research Areas >>Metabolic DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>SGLT
Target	SGLT2:2.26 nM (IC50) SGLT1:3990 nM (IC50)
In Vitro	Luseogliflozin (TS-071, 3p) is a potent sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor, with an IC50 of 2.26 nM, about 1765-fold selectivity over SGLT1 (IC50, 3990 nM); Luseogliflozin has the protential for treating type 2 diabetes[1].
In Vivo	Luseogliflozin (1 mg/kg, p.o.) exhibits a blood glucose lowering effect, excellent urinary glucose excretion properties, and promising PK profiles in rats and dogs[1].

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	624.5±55.0 °C at 760 mmHg
Melting Point	155.0-157.0℃
Molecular Formula	C₂₃H₃₀O₆S
Molecular Weight	434.546
Flash Point	331.5±31.5 °C
Exact Mass	434.176300
PSA	124.68000
LogP	4.43
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.616
InChIKey	WHSOLWOTCHFFBK-ZQGJOIPISA-N
SMILES	CCOc1ccc(Cc2cc(C3SC(CO)C(O)C(O)C3O)c(OC)cc2C)cc1

Synonyms

TS-071

Luseogliflozin

Lusefi

(1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol

D-Glucitol, 1,5-anhydro-1-C-[5-[(4-ethoxyphenyl)methyl]-2-methoxy-4-methylphenyl]-1-thio-, (1S)-

UNII-C596HWF74Z

TS-71

TS 071

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