Introduction：Basic information about CAS 760981-83-7|Solithromycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Solithromycin |
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| CAS Number | 760981-83-7 | Molecular Weight | 845.009 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 969.2±75.0 °C at 760 mmHg |
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| Molecular Formula | C43H65FN6O10 | Melting Point | / |
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| MSDS | / | Flash Point | 539.9±37.1 °C |
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Names
| Name | Solithromycin |
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| Synonym | More Synonyms |
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Solithromycin BiologicalActivity
| Description | Solithromycin is a novel fluoroketolide with improved antimicrobial effectiveness.Target: AntibacterialSolithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. The mean 50% inhibitory concentrations (IC50s) for Solithromycin inhibition of cell viability, protein synthesis, and growth rate were 7.5, 40, and 125 ng/ml for Streptococcus pneumoniae,Staphylococcus aureus, and Haemophilus influenzae, respectively. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
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| References | [1]. Rodgers W, et al. Solithromycin inhibition of protein synthesis and ribosome biogenesis in Staphylococcus aureus,Streptococcus pneumoniae, and Haemophilus influenzae. Antimicrob Agents Chemother. 2013 Apr;57(4):1632-1637. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 969.2±75.0 °C at 760 mmHg |
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| Molecular Formula | C43H65FN6O10 |
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| Molecular Weight | 845.009 |
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| Flash Point | 539.9±37.1 °C |
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| Exact Mass | 844.474609 |
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| PSA | 197.87000 |
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| LogP | 3.44 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.591 |
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| InChIKey | IXXFZUPTQVDPPK-QIFQIIIXSA-N |
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| SMILES | CCC1OC(=O)C(C)(F)C(=O)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(OC)CC(C)C(=O)C(C)C2N(CCCCn3cc(-c4cccc(N)c4)nn3)C(=O)OC12C |
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| Storage condition | -20℃ |
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Synonyms
| Solithromycin |
| (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-{4-[4-(3-Aminophenyl)-1H-1,2,3-triazol-1-yl]butyl}-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4 ;,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside |
| 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 1-[4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-[[3,4,6-trideox ;y-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)- |
