CAS 372151-71-8|Telavancin

Introduction：Basic information about CAS 372151-71-8|Telavancin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Telavancin BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Telavancin
CAS Number	372151-71-8	Molecular Weight	1755.63000
Density	/	Boiling Point	/
Molecular Formula	C₈₀H₁₀₆Cl₂N₁₁O₂₇P	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	telavancin
Synonym	More Synonyms

Telavancin BiologicalActivity

Description	Telavancin (TD-6424) is a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). Telavancin disrupts cell membrane integrity, can be used for research of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria[1].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial
In Vitro	Telavancin has a rapid, concentration-dependent bactericidal effect, due to disruption of cell membrane integrity[1]. Telavancin (5 μg/mL) exerts bacteriocidal effect against a MRSA strain (COL) and a VISA strain (HIP5836) at a concentration of 5 µg/mL[1].
In Vivo	Telavancin has been tested in various relevant animal models of infection, namely, bacteremia (40 mg/kg/d; s.c.; twice a day, with 12 h space), endocarditis (30 mg/kg/d; i.v.; twice a day, with 12 h space; 4 d), meningitis, and pneumonia with success[1] Animal Model: MRSA bacteremia model in neutropenic mice[1] Dosage: 40 mg/kg Administration: Subcutaneous injection; twice every day spaced 12 h apart Result: Resulted a significantly higher 14-day survival compared with vancomycin-treated animals. Animal Model: Rabbit model of S. aureus endocarditis[1] Dosage: 30 mg/kg Administration: Intravenous injection; twice every day, spaced 12 h for 4 days Result: Significantly reduced MRSA densities in all target tissues and increased the percentage of these organs rendered culture negative.
References	[1]. Das B, et al. Telavancin: a novel semisynthetic lipoglycopeptide agent to counter the challenge of resistant Gram-positive pathogens. Ther Adv Infect Dis. 2017 Mar;4(2):49-73.

Chemical & Physical Properties

Molecular Formula	C₈₀H₁₀₆Cl₂N₁₁O₂₇P
Molecular Weight	1755.63000
Exact Mass	1753.64000
PSA	607.90000
LogP	6.99100
InChIKey	ONUMZHGUFYIKPM-MXNFEBESSA-N
SMILES	CCCCCCCCCCNCCNC1(C)CC(OC2C(Oc3c4cc5cc3Oc3ccc(cc3Cl)C(O)C3NC(=O)C(NC(=O)C5NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)c5ccc(c(Cl)c5)O4)c4ccc(O)c(c4)-c4c(cc(O)c(CNCP(=O)(O)O)c4O)C(C(=O)O)NC3=O)OC(CO)C(O)C2O)OC(C)C1O

Synonyms

Vancomycin, N3''-[2-(decylamino)ethyl]-29-[[(phosphonomethyl)amino]methyl]-

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