Introduction：Basic information about CAS 64183-27-3|2′-Deoxy-2′-fluoroadenosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2′-Deoxy-2′-fluoroadenosine |
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| CAS Number | 64183-27-3 | Molecular Weight | 269.232 |
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| Density | 2.0±0.1 g/cm3 | Boiling Point | 628.6±65.0 °C at 760 mmHg |
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| Molecular Formula | C10H12FN5O3 | Melting Point | / |
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| MSDS | / | Flash Point | 334.0±34.3 °C |
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Names
| Name | (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol |
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| Synonym | More Synonyms |
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2′-Deoxy-2′-fluoroadenosine BiologicalActivity
| Description | 2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde) and shows excellent in vivo activity against tumors expressing E. coli PNP[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
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| References | [1]. A E Hassan, et al. A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):559-65. |
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Chemical & Physical Properties
| Density | 2.0±0.1 g/cm3 |
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| Boiling Point | 628.6±65.0 °C at 760 mmHg |
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| Molecular Formula | C10H12FN5O3 |
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| Molecular Weight | 269.232 |
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| Flash Point | 334.0±34.3 °C |
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| Exact Mass | 269.092407 |
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| PSA | 119.31000 |
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| LogP | -0.32 |
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| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
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| Index of Refraction | 1.834 |
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| InChIKey | ZGYYPTJWJBEXBC-QYYRPYCUSA-N |
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| SMILES | Nc1ncnc2c1ncn2C1OC(CO)C(O)C1F |
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2'F-dA |
| 2'-Deoxy-2'-fluoroadenosine |
| 2'-fluoro-2'-deoxy-adenosine |
| Adenosine, 2'-deoxy-2'-fluoro- |
| Adenosine,2'-deoxy-2'-fluoro |
