Introduction：Basic information about CAS 64519-82-0|glucosylmannitol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes[1].
Related Catalog
Signaling Pathways >>Metabolic Enzyme/Protease >>Lactate DehydrogenaseResearch Areas >>Metabolic Disease
In Vivo
The chronic toxicity of orally administered isomalt as a part of diet has been studied in animals and it was found to be a safe substance. It did not affect the mortality rate of the animals, and there was no evidence of carcinogenicity, or adverse effects on fertility, reproductive performance or development[1].
References
[1]. Tuderman AK, et al. Isomalt and its diastereomer mixtures as stabilizing excipients with freeze-dried lactate dehydrogenase. Int J Pharm. 2018 Mar 1;538(1-2):287-295.
Chemical & Physical Properties
Density
1.7±0.1 g/cm3
Boiling Point
788.5±60.0 °C at 760 mmHg
Melting Point
215-217°C
Molecular Formula
C12H24O11
Molecular Weight
344.312
Flash Point
430.7±32.9 °C
Exact Mass
344.131866
PSA
401.06000
LogP
-5.72
Vapour Pressure
0.0±6.2 mmHg at 25°C
Index of Refraction
1.634
InChIKey
SERLAGPUMNYUCK-BLEZHGCXSA-N
SMILES
OCC(O)C(O)C(O)C(O)COC1OC(CO)C(O)C(O)C1O
Storage condition
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
LZ4394500
CHEMICAL NAME :
D-Glucitol, 6-O-alpha-D-glucopyranosyl-, mixed with 1-O-alpha-D-glucopyranosyl-D-mannitol
CAS REGISTRY NUMBER :
64519-82-0
LAST UPDATED :
199312
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H24-O11.C12-H24-O11
MOLECULAR WEIGHT :
688.72
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
125 mg/kg
SEX/DURATION :
female 5 day(s) pre-mating female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 27,631,1989
Safety Information
Hazard Codes
Xn
Risk Phrases
R20/21/22
Safety Phrases
22-26-36/37/39-45
RIDADR
NONH for all modes of transport
RTECS
LZ4394500
HS Code
2940000000
Customs
HS Code
2940000000
Articles25
More Articles
Assessment of isomalt for colon-specific delivery and its comparison with lactulose.
AAPS PharmSciTech 14(1) , 53-9, (2013)
Lactulose is used as a triggering substance in a unique colon-specific delivery technology called CODESTM. Colonic microflora degrades lactulose and forms short-chain fatty acids to activate the CODES...
Effect of isomalt consumption on faecal microflora and colonic metabolism in healthy volunteers.
Br. J. Nutr. 95(1) , 40-50, (2006)
Due to its low digestibility in the small intestine, a major fraction of the polyol isomalt reaches the colon. However, little is known about effects on the intestinal microflora. During two 4-week pe...
Effects of isomalt consumption on gastrointestinal and metabolic parameters in healthy volunteers.
Br. J. Nutr. 94(4) , 575-81, (2005)
The polyol isomalt (Palatinit) is a well established sugar replacer. The impact of regular isomalt consumption on metabolism and parameters of gut function in nineteen healthy volunteers was examined ...
