CAS 71-62-5|Veratridine

Introduction：Basic information about CAS 71-62-5|Veratridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Veratridine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles53
8. Synonyms

Common Name	Veratridine
CAS Number	71-62-5	Molecular Weight	673.79000
Density	1.45 g/cm3	Boiling Point	814.5ºC at 760 mmHg
Molecular Formula	C₃₆H₅₁NO₁₁	Melting Point	180ºC
MSDS	ChineseUSA	Flash Point	446.4ºC
Symbol	GHS06, GHS08	Signal Word	Danger

Names

Name	veratridine
Synonym	More Synonyms

Veratridine BiologicalActivity

Description	Veratridine (3-Veratroylveracevine), a alkaloid derived from plants in the family Liliaceae, is a sodium channel agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM.
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Neurological Disease
References	[1]. Zhang XY, et al. Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7. Acta Pharmacol Sin. 2018 Nov;39(11):1716-1724.

Chemical & Physical Properties

Density	1.45 g/cm3
Boiling Point	814.5ºC at 760 mmHg
Melting Point	180ºC
Molecular Formula	C₃₆H₅₁NO₁₁
Molecular Weight	673.79000
Flash Point	446.4ºC
Exact Mass	673.34600
PSA	178.61000
LogP	1.29390
Index of Refraction	1.663
InChIKey	FVECELJHCSPHKY-YFUMOZOISA-N
SMILES	COc1ccc(C(=O)OC2CCC3(C)C4CCC5C6(O)CC(O)C7(O)C(CN8CC(C)CCC8C7(C)O)C6(O)CC53OC24O)cc1OC

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YX5600000

CHEMICAL NAME :: Veratridine

CAS REGISTRY NUMBER :: 71-62-5

BEILSTEIN REFERENCE NO. :: 0078875

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C36-H51-N-O11

MOLECULAR WEIGHT :: 673.88

WISWESSER LINE NOTATION :: T J6 H6 E6 D5665/TC& 3ATU C& ON TX C&OTJ EQ GQ HQ IQ I1 M1 RQ U1 A&OVR CO1 DO1& B&Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3500 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 78,238,1943

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 76,847,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,89,1955

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction)

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 120,412,1957

Safety Information

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H300 + H310 + H330-H315-H319-H335-H361-H373-H412
Precautionary Statements	P260-P262-P280-P301 + P310 + P330-P302 + P352 + P310-P304 + P340 + P310-P403 + P233
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;
Risk Phrases	R26/27/28
Safety Phrases	S26;S36/S37/S39;S45
RIDADR	UN 1544 6
WGK Germany	2
RTECS	YX5600000
Packaging Group	II
Hazard Class	6.1(a)
HS Code	2929101000

Customs

HS Code	2929101000
Summary	2929101000. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles53

Ikarisoside A inhibits acetylcholine-induced catecholamine secretion and synthesis by suppressing nicotinic acetylcholine receptor-ion channels in cultured bovine adrenal medullary cells.

Naunyn Schmiedebergs Arch. Pharmacol. 388 , 1259-69, (2015)

Ikarisoside A is a natural flavonol glycoside derived from plants of the genus Epimedium, which have been used in Traditional Chinese Medicine as tonics, antirheumatics, and aphrodisiacs. Here, we rep...

Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies).

Environ. Res. 143 , 100-8, (2015)

From 2010 to 2012, 35 ciguatera fish poisoning (CFP) events involving 87 individuals who consumed locally-caught fish were reported in Guadeloupe (French West Indies). For 12 of these events, the pres...

Voltage-activated calcium channels involved in veratridine-evoked [3H]dopamine release in rat striatal slices.

Neuropharmacology 37 , 973-982, (1998)

The present study explored the role of different sub-types of voltage-activated Ca2+ channels (VACCs) in mediating veratridine-evoked [3H]dopamine (DA) release from rat striatal slices. The release of...

Synonyms

Metergoline

,4alpha,16beta)

EINECS 200-758-4

Veracevine,veratrate

ybenzoate)

VERATRIDINE

3-VERATROYLVERACEVINE

MFCD00082515

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