CAS 299430-87-8|Fmoc-N-amido-PEG2-alcohol

Introduction：Basic information about CAS 299430-87-8|Fmoc-N-amido-PEG2-alcohol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameFmoc-N-amido-PEG2-alcohol
CAS Number299430-87-8Molecular Weight327.37400
Density1.221g/cm3Boiling Point547.8ºC at 760 mmHg
Molecular FormulaC19H21NO4Melting Point/
MSDSChineseUSAFlash Point285.1ºC

Names

Name9H-fluoren-9-ylmethyl N-[2-(2-hydroxyethoxy)ethyl]carbamate
SynonymMore Synonyms

Fmoc-N-amido-PEG2-alcohol BiologicalActivity

DescriptionFmoc-N-amido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

PEGs

In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Density1.221g/cm3
Boiling Point547.8ºC at 760 mmHg
Molecular FormulaC19H21NO4
Molecular Weight327.37400
Flash Point285.1ºC
Exact Mass327.14700
PSA67.79000
LogP2.92490
Vapour Pressure7.81E-13mmHg at 25°C
Index of Refraction1.588
InChIKeyDUVHQSUZTXSLMW-UHFFFAOYSA-N
SMILESO=C(NCCOCCO)OCC1c2ccccc2-c2ccccc21
Storage condition2-8°C

Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADRNONH for all modes of transport

Synonyms

AmbotzFAL3010
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