CAS 118068-30-7|Amylin (20-29) (human)

Introduction：Basic information about CAS 118068-30-7|Amylin (20-29) (human), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Amylin (20-29) (human) BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Amylin (20-29) (human)
CAS Number	118068-30-7	Molecular Weight	1009.07
Density	/	Boiling Point	/
Molecular Formula	C₄₃H₆₈N₁₂O₁₆	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	h-ser-asn-asn-phe-gly-ala-ile-leu-ser-ser-oh
Synonym	More Synonyms

Amylin (20-29) (human) BiologicalActivity

Description	Amylin (20-29) (human) is the fragment of human islet amyloid polypeptide (hIAPP) or Amylin. Amylin is a 37-residue hormone. Amylin (20-29) (human) is responsible for the amyloidogenic propensities of the full length protein. Amylin (20-29) (human) can be transformed into its corresponding peptoid and retropeptoid sequences, to obtain beta-sheet breaker peptides as amyloid inhibitors[1][2].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. Kapurniotu A, et al. Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity. J Mol Biol. 2002 Jan 18;315(3):339-50. [2]. Elgersma RC, et al. Transformation of the amyloidogenic peptide amylin(20-29) into its corresponding peptoid and retropeptoid: access to both an amyloid inhibitor and template for self-assembled supramolecular tapes. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1837-42.

Description

Amylin (20-29) (human) is the fragment of human islet amyloid polypeptide (hIAPP) or Amylin. Amylin is a 37-residue hormone. Amylin (20-29) (human) is responsible for the amyloidogenic propensities of the full length protein. Amylin (20-29) (human) can be transformed into its corresponding peptoid and retropeptoid sequences, to obtain beta-sheet breaker peptides as amyloid inhibitors[1][2].

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

References

[1]. Kapurniotu A, et al. Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity. J Mol Biol. 2002 Jan 18;315(3):339-50.

[2]. Elgersma RC, et al. Transformation of the amyloidogenic peptide amylin(20-29) into its corresponding peptoid and retropeptoid: access to both an amyloid inhibitor and template for self-assembled supramolecular tapes. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1837-42.

Chemical & Physical Properties

Molecular Formula	C₄₃H₆₈N₁₂O₁₆
Molecular Weight	1009.07
Exact Mass	1008.49000
PSA	472.09000
InChIKey	RMSCIVKVSZSEHU-UHFFFAOYSA-N
SMILES	CCC(C)C(NC(=O)C(C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(N)CO)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CO)C(=O)O

Safety Information

Safety Phrases	22-24/25
WGK Germany	3

Synonyms

AMYLIN FRAGMENT 20-29 HUMAN

SER-ASN-ASN-PHE-GLY-ALA-ILE-LEU-SER-SER

diabetes associated peptide fragment 20-29 human

SNNFGAILSS

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