Introduction：Basic information about CAS 521-32-4|Bilobetin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bilobetin |
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| CAS Number | 521-32-4 | Molecular Weight | 552.484 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 869.9±65.0 °C at 760 mmHg |
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| Molecular Formula | C31H20O10 | Melting Point | 296-298ºC |
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| MSDS | / | Flash Point | 291.9±27.8 °C |
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Names
| Name | 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one |
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| Synonym | More Synonyms |
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Bilobetin BiologicalActivity
| Description | Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity[1]. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>PKASignaling Pathways >>Stem Cell/Wnt >>PKASignaling Pathways >>Cell Cycle/DNA Damage >>PPARResearch Areas >>Metabolic Disease |
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| Target | PPARα PKA |
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| References | [1]. Kou XH, et al. Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet. Br J Pharmacol. 2012 Apr;165(8):2692-706. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 869.9±65.0 °C at 760 mmHg |
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| Melting Point | 296-298ºC |
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| Molecular Formula | C31H20O10 |
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| Molecular Weight | 552.484 |
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| Flash Point | 291.9±27.8 °C |
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| Exact Mass | 552.105652 |
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| PSA | 170.80000 |
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| LogP | 4.20 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.750 |
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| InChIKey | IWEIJEPIYMAGTH-UHFFFAOYSA-N |
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| SMILES | COc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1-c1c(O)cc(O)c2c(=O)cc(-c3ccc(O)cc3)oc12 |
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Safety Information
Synonyms
| 3''',8-Biflavone,4',5,5'',7,7''-pentahydroxy-4'''-methoxy |
| 4'-monomethylamentoflavone |
| 4'-methylamentoflavone |
| 8-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one |
| Bilobetin |
| 4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)- |
| 4'-O-methylamentoflavone |
