Introduction：Basic information about CAS 79700-61-1|Dopropidil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dopropidil |
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| CAS Number | 79700-61-1 | Molecular Weight | 321.49700 |
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| Density | 0.99g/cm3 | Boiling Point | 413ºC at 760 mmHg |
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| Molecular Formula | C20H35NO2 | Melting Point | / |
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| MSDS | / | Flash Point | 113ºC |
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Names
| Name | Dopropidil |
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| Synonym | More Synonyms |
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Dopropidil BiologicalActivity
| Description | Dopropidil is a novel anti-anginal calcium ion modulating agent, possessing intracellular calcium antagonist activity and anti-ischemic effects in several predictive animal models. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Cardiovascular Disease |
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| Target | Calcium[1] |
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| In Vitro | Dopropidil is able to inhibit caffeine-induced contractions of rabbit renal arteries in a calcium-free medium (IC50=30.0 uM). Dopropidil inhibits norepinephnne (NE)-induced responses with IC50s of 2.7 and 29.8 uM, respectively. At 3 and 10 μM, Dopropidil significantly reduces the maximum increase in diastolic tension evoked by veratrine (IC50=2.8 μM)[1]. |
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| In Vivo | Dopropidil (1 and 2.5 mg/kg) dose-dependently reduces the electrical (ST segment elevation), biochemical (lactate production and potassium release), and mechanical (loss in myocardial segment contractility) perturbations induced by ischemia in the anesthetized dog. Intraduodenal administration of Dopropidil (50 mg/kg) significantly reduces isoproterenol-induced tachycardia. This effect is manifest at 15-120 min following administration of the compound which indicates a rapid absorption and a long duration of action. In conscious dogs Dopropidil (12-14 mg/kg p.o.) reduces resting heart rate by approximately10 beats/min[1]. |
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| Animal Admin | Rabbits[1] Groups of rabbits given a normal diet or one containing Cholesterol (1 %) are treated with vehicle, Diltiazem (10 mg/kg per day,p.o.), or Dopropidil (30 mg/kg per day, p.o.) over a 14-week period. Animals are then killed and certain blood vessels examined macroscopically, microscopically, and pharmacologically for reactivity to certain vasoactive agents. |
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| References | [1]. J. Planellas, et al. Dopropidil, A Novel Antianginal Calcium Modulating Agent. Cardiovascular Drug Reviews. Vol.12, No.3, pp. 208-224. |
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Chemical & Physical Properties
| Density | 0.99g/cm3 |
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| Boiling Point | 413ºC at 760 mmHg |
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| Molecular Formula | C20H35NO2 |
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| Molecular Weight | 321.49700 |
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| Flash Point | 113ºC |
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| Exact Mass | 321.26700 |
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| PSA | 21.70000 |
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| LogP | 3.80410 |
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| Index of Refraction | 1.504 |
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| InChIKey | FITWYAUFKJXWPL-UHFFFAOYSA-N |
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| SMILES | CC#CC1(OCC(COCC(C)C)N2CCCC2)CCCCC1 |
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| Storage condition | 2-8℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UY1471250
- CHEMICAL NAME :
- Pyrrolidine, 1-(1-((2-methylpropoxy)methyl)-2-((1-(1-propynyl)cycl ohexyl)oxy)ethyl)-
- CAS REGISTRY NUMBER :
- 79700-61-1
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H35-N-O2
- MOLECULAR WEIGHT :
- 321.56
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4430332
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Synonyms
