Introduction：Basic information about CAS 6038-59-1|3’-O-Methyluridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
3’-O-Methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
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Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog
References
[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
Differentiation of 2'-O- and 3'-O-methylated ribonucleosides by tandem mass spectrometry.
J. Am. Soc. Mass Spectrom. 17 , 1096-1099, (2006)
Recent studies revealed that the 3'-terminal nucleotides in plant microRNAs were methylated on the ribose at the 2' or 3' hydroxyl groups. Here we examined the fragmentation of the electrospray-produc...
