CAS 62480-44-8|L-LEUCINE-7-AMINO-4-METHYLCOUMARIN HCL
Introduction：Basic information about CAS 62480-44-8|L-LEUCINE-7-AMINO-4-METHYLCOUMARIN HCL, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro[1].
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In Vitro
In leucine aminopeptidases inhibition assays in KB 3.1 cells. Compounds 3 and 5 are observed to weakly inhibit the biofilm formation by S. aureus and constrain inhibitory activity of ʟ-Leu-AMC hydrolysis in KB 3.1 cells[1]. The amount of hydrolyzed 7-amino-4-methylcoumarin (AMC) is determined in a fluorescence spectrophotometer (excitation/emission: 365/440 nm)[1].
References
[1]. Tian Cheng, et al. Skeletocutins M-Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa. Beilstein J Org Chem
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