Introduction：Basic information about CAS 485-19-8|Reticuline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Reticuline |
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| CAS Number | 485-19-8 | Molecular Weight | 329.390 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 504.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C19H23NO4 | Melting Point | 125-126ºC |
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| MSDS | / | Flash Point | 259.2±30.1 °C |
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Names
| Name | reticuline |
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| Synonym | More Synonyms |
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Reticuline BiologicalActivity
| Description | Reticuline, isolated from Litsea cubeba, shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3[1]. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>STATSignaling Pathways >>JAK/STAT Signaling >>JAKSignaling Pathways >>Epigenetics >>JAKSignaling Pathways >>Stem Cell/Wnt >>JAKSignaling Pathways >>JAK/STAT Signaling >>STATResearch Areas >>Inflammation/Immunology |
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| Target | JAK2 STAT3 NF-κB |
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| References | [1]. Yang X, et al. Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways. Planta Med. 2018 Jan;84(1):20-25. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 504.9±50.0 °C at 760 mmHg |
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| Melting Point | 125-126ºC |
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| Molecular Formula | C19H23NO4 |
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| Molecular Weight | 329.390 |
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| Flash Point | 259.2±30.1 °C |
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| Exact Mass | 329.162720 |
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| PSA | 62.16000 |
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| LogP | 2.09 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.604 |
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| InChIKey | BHLYRWXGMIUIHG-HNNXBMFYSA-N |
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| SMILES | COc1ccc(CC2c3cc(O)c(OC)cc3CCN2C)cc1O |
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| Storage condition | -20?C Freezer |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NX5993000
- CHEMICAL NAME :
- 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-((3-hydroxy-4-methoxyphenyl)meth yl)-6-methoxy-2-methy l-,(S)-
- CAS REGISTRY NUMBER :
- 485-19-8
- BEILSTEIN REFERENCE NO. :
- 4299976
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C19-H23-N-O4
- MOLECULAR WEIGHT :
- 329.43
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JNPRDF Journal of Natural Products. (Spahr & Glenn Co., 225 E. Spring St., Columbus, OH 43215) V.42- 1979- Volume(issue)/page/year: 42,399,1979
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Safety Information
Synonyms
| 1-(3-Hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol |
| Reticuline |
| 1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinol |
| 2-Methyl-7-hydroxy-6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline |
| 1-(3-Hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-7-isoquinolinol |
| Coclanoline |
| (±)-Reticuline |
| 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl- |
