Introduction：Basic information about CAS 63283-42-1|Salsolidine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Salsolidine hydrochloride |
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| CAS Number | 63283-42-1 | Molecular Weight | 243.73 |
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| Density | / | Boiling Point | 313.4ºC at 760 mmHg |
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| Molecular Formula | C12H18ClNO2 | Melting Point | 189-192ºC |
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| MSDS | / | Flash Point | 127.1ºC |
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Names
| Name | 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline,hydrochloride |
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| Synonym | More Synonyms |
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Salsolidine hydrochloride BiologicalActivity
| Description | Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Neurological Disease |
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| Target | MAO A[1] |
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| In Vitro | Salsolidine hydrochloride is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. The R-salsolidine is more active against MAO A than S-salsolidine (Ki=6 μM and 186 μM)[1]. Salsolidine weakly inhibits the binding of δ-receptor, with a Ki of >100 μM[2]. Salsolidine has the potential of inhibiting acetylcholinestearse and butyrylcholinesterase[3]. |
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| References | [1]. Bembenek ME, et al. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52. [2]. Airaksinen MM, et al. Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5. [3]. Tundis R, et al. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2009 Jun;24(3):818-24. |
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Chemical & Physical Properties
| Boiling Point | 313.4ºC at 760 mmHg |
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| Melting Point | 189-192ºC |
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| Molecular Formula | C12H18ClNO2 |
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| Molecular Weight | 243.73 |
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| Flash Point | 127.1ºC |
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| Exact Mass | 243.10300 |
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| PSA | 30.49000 |
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| LogP | 3.04130 |
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| InChIKey | UJXLTDHDLUBZBL-UHFFFAOYSA-N |
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| SMILES | COc1cc2c(cc1OC)C(C)NCC2.Cl |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NX5018600
- CHEMICAL NAME :
- Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 63283-42-1
- LAST UPDATED :
- 198806
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C12-H17-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 243.76
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 189 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 76,263,1942
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Synonyms
| Salsolidine hydrochloride |
| Prestwick_860 |
| Isoquinoline,6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro,hydrochloride |
| Salsolidin*HCl |
