CAS 330161-87-0|SU6656

Introduction:Basic information about CAS 330161-87-0|SU6656, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameSU6656
CAS Number330161-87-0Molecular Weight371.453
Density1.4±0.1 g/cm3Boiling Point/
Molecular FormulaC19H21N3O3SMelting Point/
MSDSChineseUSAFlash Point/

Names

Namesu 6656
SynonymMore Synonyms

SU6656 BiologicalActivity

DescriptionSU 6656 is a Src family kinases inhibitor with IC50s of 280, 20, 130, 170 nM for Src, Yes, Lyn, and Fyn, respectively.
Related CatalogSignaling Pathways >>Protein Tyrosine Kinase/RTK >>SrcResearch Areas >>Cancer
References

[1]. Blake RA, et al. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol. 2000 Dec;20(23):9018-27.

[2]. Veracini L, et al. Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas. Oncotarget. 2014 Dec 26.

[3]. Wu ML, et al. Divergent signaling pathways cooperatively regulate TGFβ induction of cysteine-rich protein 2 in vascular smooth muscle cells. Cell Commun Signal. 2014 Mar 28;12:22.

[4]. Ondrusová L, et al. Inhibition of mTORC1 by SU6656, the selective Src kinase inhibitor, is not accompanied by activation of Akt/PKB signalling in melanoma cells. Folia Biol (Praha). 2013;59(4):162-7.

[5]. Kumar A, et al. Pharmacological investigations on possible role of Src kinases in neuroprotective mechanism of ischemic postconditioning in mice. Int J Neurosci. 2014 Oct;124(10):777-86.

[6]. Liu XF, et al. Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors. Mol Cancer Ther. 2014 Jan;13(1):82-9.

Chemical & Physical Properties

Density1.4±0.1 g/cm3
Molecular FormulaC19H21N3O3S
Molecular Weight371.453
Exact Mass371.130371
PSA90.65000
LogP3.46
Index of Refraction1.657
InChIKeyLOGJQOUIVKBFGH-YBEGLDIGSA-N
SMILESCN(C)S(=O)(=O)c1ccc2c(c1)C(=Cc1cc3c([nH]1)CCCC3)C(=O)N2
Storage condition-20℃

Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard CodesN
RIDADRNONH for all modes of transport

Articles4

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Methods producing human platelets using growth on plastic, on feeder layers, or in suspension have been described. We hypothesized that growth of hematopoietic progenitors in a three-dimensional (3D) ...

Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.

Nat. Commun. 5 , 5092, (2014)

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Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells.

Am. J. Physiol. Cell Physiol. 290(2) , C463-71, (2006)

Cortactin, a predominant substrate of Src family kinases, plays an important role in Arp2/3-dependent actin polymerization in lamellipodia and membrane ruffles and was recently shown to be enriched in...

Synonyms

1H-Indole-5-sulfonamide, 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-, (3Z)-
(3Z)-N,N-Dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-5-indolinesulfonamide
(3Z)-N,N-Dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)indoline-5-sulfonamide
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