CAS 3326-34-9|5-Aminofluorescein

Introduction：Basic information about CAS 3326-34-9|5-Aminofluorescein, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 5-Aminofluorescein BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles30
7. Synonyms

Common Name	5-Aminofluorescein
CAS Number	3326-34-9	Molecular Weight	347.321
Density	1.6±0.1 g/cm3	Boiling Point	695.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₃NO₅	Melting Point	223ºC
MSDS	ChineseUSA	Flash Point	374.3±31.5 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	6-amino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
Synonym	More Synonyms

5-Aminofluorescein BiologicalActivity

Description	5-Aminofluorescein (5-AF) is a new fluorescence marker, covalently bound to human serum albumin (AFL-HSA) [1]5-aminofluorescein is a pH-sensitive biomaterial, is the targeted prodrug for synthesis of FA-FITC-Arg-PTX and FA-5AF- Glu-PTX..
Related Catalog	Signaling Pathways >>Others >>OthersDye ReagentsResearch Areas >>Others
References	[1]. Ding R, et al. Pharmacokinetics of 5-aminofluorescein-albumin, a novel fluorescence marker of brain tumors during surgery. J Clin Pharmacol. 2011 May;51(5):672-8. [2]. Miao R, et al. Facile method for modification of the silicon nanowires and its application in fabrication of pH-sensitive chips. ACS Appl Mater Interfaces. 2013 Mar 13;5(5):1741-6. [3]. Wang T, et al. Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein. J Am Chem Soc. 2015 Nov 4;137(43):13736-9. [4]. Shan L, et al. Multi-small molecule conjugations as new targeted delivery carriers for tumor therapy. Int J Nanomedicine. 2015 Sep 1;10:5571-91.

Description

5-Aminofluorescein (5-AF) is a new fluorescence marker, covalently bound to human serum albumin (AFL-HSA) [1]5-aminofluorescein is a pH-sensitive biomaterial, is the targeted prodrug for synthesis of FA-FITC-Arg-PTX and FA-5AF- Glu-PTX..

Related Catalog

Signaling Pathways >>Others >>OthersDye ReagentsResearch Areas >>Others

References

[1]. Ding R, et al. Pharmacokinetics of 5-aminofluorescein-albumin, a novel fluorescence marker of brain tumors during surgery. J Clin Pharmacol. 2011 May;51(5):672-8.

[2]. Miao R, et al. Facile method for modification of the silicon nanowires and its application in fabrication of pH-sensitive chips. ACS Appl Mater Interfaces. 2013 Mar 13;5(5):1741-6.

[3]. Wang T, et al. Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein. J Am Chem Soc. 2015 Nov 4;137(43):13736-9.

[4]. Shan L, et al. Multi-small molecule conjugations as new targeted delivery carriers for tumor therapy. Int J Nanomedicine. 2015 Sep 1;10:5571-91.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	695.3±55.0 °C at 760 mmHg
Melting Point	223ºC
Molecular Formula	C₂₀H₁₃NO₅
Molecular Weight	347.321
Flash Point	374.3±31.5 °C
Exact Mass	347.079376
PSA	102.01000
LogP	1.80
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.820
InChIKey	GZAJOEGTZDUSKS-UHFFFAOYSA-N
SMILES	Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21
Storage condition	2-8°C
Stability	Light and Moisture Sensitive

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2921199090

Customs

HS Code	2921199090
Summary	2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles30

Verrucomicrobia are candidates for polysaccharide-degrading bacterioplankton in an arctic fjord of Svalbard.

Appl. Environ. Microbiol. 80(12) , 3749-56, (2014)

In Arctic marine bacterial communities, members of the phylum Verrucomicrobia are consistently detected, although not typically abundant, in 16S rRNA gene clone libraries and pyrotag surveys of the ma...

Design, Synthesis, and Therapeutic Evaluation of Poly(acrylic acid)-tetraDOCA Conjugate as a Bile Acid Transporter Inhibitor.

Bioconjug. Chem. 26 , 1597-605, (2015)

Regulation of cholesterol and bile acid homeostasis has been attracting attention as a pharmaceutical target for the treatment of diseases, such as hypercholesterolaemia and type 2 diabetes. In recent...

Molecular basis for premature senescence induced by surfactants in normal human cells.

Biosci. Biotechnol. Biochem. 78(12) , 2022-9, (2014)

Sublethal doses of surfactants as exemplified by NP-40 clearly induce premature senescence in normal human cells. To understand molecular basis for this phenomenon, we tried to suppress it with use of...

Synonyms

Fluoresceinamine (isomer I)

Fluoresceinamine

1-AMINOFLUORESCEIN

5-Amino-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5-amino-3',6'-dihydroxy-

1-FLUORESCEINAMINE

EINECS 222-043-6

Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-amino-3',6'-dihydroxy-

FLUORESCEINAMINE ISOMER I

4-AMINOFLUORESCEIN ISOMER I

MFCD00005052

5-Aminofluorescein

AMINOFLUORESCEIN

5-Amino-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-on

FLUORESCEINAMINE,ISOMER 1

5-fluorescein amine

Fluoresceinamine-I

5-Aminofluorescein (isomer I)

4-AMINOFLUORESCEIN

Fluoresceinamine,isomer I

5-Amino-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one (isomer I)

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