CAS 3443-84-3|2-Oleoylglycerol
| Common Name | 2-Oleoylglycerol | ||
|---|---|---|---|
| CAS Number | 3443-84-3 | Molecular Weight | 356.54000 |
| Density | 0.969 g/cm3 | Boiling Point | 485.4ºC at 760mmHg |
| Molecular Formula | C21H40O4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 113ºC |
Names
| Name | 2-oleoylglycerol |
|---|---|
| Synonym | More Synonyms |
2-Oleoylglycerol BiologicalActivity
| Description | 2-Oleoylglycerol is a dietary naturally occurring lipid. 2-Oleoylglycerol is a GPR119 agonist, with an EC50 of 2.5 μM for human GPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol stimulates glucagon-like peptide-1 (GLP-1) secretion in vivo[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>GPR119Research Areas >>Metabolic Disease |
| Target | IC50: 2.5 μM (hGPR119) (in COS-7 cells)[1] |
| References | [1]. Hansen KB, et, al. 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. J Clin Endocrinol Metab. 2011 Sep;96(9):E1409-17. [2]. Ghafouri N, et, al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol. 2004 Nov;143(6):774-84. |
Chemical & Physical Properties
| Density | 0.969 g/cm3 |
|---|---|
| Boiling Point | 485.4ºC at 760mmHg |
| Molecular Formula | C21H40O4 |
| Molecular Weight | 356.54000 |
| Flash Point | 113ºC |
| Exact Mass | 356.29300 |
| PSA | 66.76000 |
| LogP | 4.92030 |
| Index of Refraction | 1.478 |
| InChIKey | UPWGQKDVAURUGE-KTKRTIGZSA-N |
| SMILES | CCCCCCCCC=CCCCCCCCC(=O)OC(CO)CO |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles15
More Articles| Sensing of triacylglycerol in the gut: different mechanisms for fatty acids and 2-monoacylglycerol. J. Physiol. 593(8) , 2097-109, (2015) Sensing of dietary triacylglycerol in the proximal small intestine results in physiological, hormonal and behavioural responses. However, the exact physiological pathways linking intestinal fat sensin... | |
| TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 307(2) , L158-72, (2014) The treatment of acute lung injury caused by exposure to reactive chemicals remains challenging because of the lack of mechanism-based therapeutic approaches. Recent studies have shown that transient ... | |
| Identification of 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide (29) as an orally available MGAT2 inhibitor. Bioorg. Med. Chem. 23 , 5922-31, (2015) MGAT2 (monoacylglycerol acyltransferase 2) is expected to be an attractive target for the drug treatment of obesity, diabetes, and other disease. We describe our exploration and structure-activity rel... |
Synonyms
| glycerine monooleate |
| 2-o-Kresyloxy-glutarsaeure-diethylester |
| 2-MONOOLEIN |
| 1,3-dihydroxypropan-2-yl oleate |
| 2-monooleoylglycerol |
| 2-Oleoylglycerol |
| glycerin oleate |
