Introduction：Basic information about CAS 69123-94-0|2'-Deoxy-2'-fluorouridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2'-Deoxy-2'-fluorouridine |
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| CAS Number | 69123-94-0 | Molecular Weight | 246.19 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C9H11FN2O5 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)uracil |
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| Synonym | More Synonyms |
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2'-Deoxy-2'-fluorouridine BiologicalActivity
| Description | 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/AnalogResearch Areas >>Others |
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| References | [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Molecular Formula | C9H11FN2O5 |
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| Molecular Weight | 246.19 |
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| Exact Mass | 246.065201 |
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| PSA | 104.55000 |
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| LogP | -1.31 |
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| Index of Refraction | 1.608 |
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| InChIKey | UIYWFOZZIZEEKJ-PXBUCIJWSA-N |
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| SMILES | O=c1ccn(C2OC(CO)C(O)C2F)c(=O)[nH]1 |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- YQ9512000
- CHEMICAL NAME :
- Uracil, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-
- CAS REGISTRY NUMBER :
- 69123-94-0
- LAST UPDATED :
- 198708
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C11-H15-F-N2-O5
- MOLECULAR WEIGHT :
- 274.28
- WISWESSER LINE NOTATION :
- T6NVMVJ E2 A- BT5OTJ CF DQ E1Q
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - rat Bone marrow
- DOSE/DURATION :
- 3700 umol/L
- REFERENCE :
- PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 26,333,1985
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione |
| 2'-Deoxy-2'-fluorouridine |
| 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)- |
| 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione |
| Uridine, 2'-deoxy-2'-fluoro- |
| 2'-Fluoro-2'-deoxyuridine |
| 1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)uracil |
