CAS 69308-37-8|(R)-Baclofen

Introduction：Basic information about CAS 69308-37-8|(R)-Baclofen, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (R)-Baclofen BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	(R)-Baclofen
CAS Number	69308-37-8	Molecular Weight	213.661
Density	1.3±0.1 g/cm3	Boiling Point	364.3±32.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₂ClNO₂	Melting Point	171-174°C
MSDS	/	Flash Point	174.1±25.1 °C

Names

Name	(R)-4-Amino-3-(4-chlorophenyl)butanoic acid
Synonym	More Synonyms

(R)-Baclofen BiologicalActivity

Description	(R)-Baclofen(STX209) is a selective GABAB receptor agonist. IC50 value:Target: GABAB receptorGABAB receptors are metabotropic receptors which produce slow inhibitory signals. By manipulating GABAB receptor activity using Baclofen, a variety of functions are studied including synaptic transmissions and antinociception events.
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA ReceptorResearch Areas >>Neurological Disease
References	[1]. Falch E, Hedegaard A, Nielsen L et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47(3):898-903. [2]. Hong YG, Henry JL. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196(3):267-75. [3]. Orsnes G, Crone C, Krarup C et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111(8):1372-9. [4]. Colombo G, Addolorato G, Agabio R et al. Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res. 2004;6(5):403-14. [5]. Stetkarova I, Yablon SA, Kofler M, Stokic DS. Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review. Neurorehabil Neural Repair. 2010 Sep;24(7):609-19.

Description

(R)-Baclofen(STX209) is a selective GABAB receptor agonist. IC50 value:Target: GABAB receptorGABAB receptors are metabotropic receptors which produce slow inhibitory signals. By manipulating GABAB receptor activity using Baclofen, a variety of functions are studied including synaptic transmissions and antinociception events.

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA ReceptorResearch Areas >>Neurological Disease

References

[1]. Falch E, Hedegaard A, Nielsen L et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47(3):898-903.

[2]. Hong YG, Henry JL. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196(3):267-75.

[3]. Orsnes G, Crone C, Krarup C et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111(8):1372-9.

[4]. Colombo G, Addolorato G, Agabio R et al. Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res. 2004;6(5):403-14.

[5]. Stetkarova I, Yablon SA, Kofler M, Stokic DS. Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review. Neurorehabil Neural Repair. 2010 Sep;24(7):609-19.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	364.3±32.0 °C at 760 mmHg
Melting Point	171-174°C
Molecular Formula	C₁₀H₁₂ClNO₂
Molecular Weight	213.661
Flash Point	174.1±25.1 °C
Exact Mass	213.055649
PSA	63.32000
LogP	1.56
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.577
InChIKey	KPYSYYIEGFHWSV-QMMMGPOBSA-N
SMILES	NCC(CC(=O)O)c1ccc(Cl)cc1
Storage condition	Store at RT

Synonyms

(R)-(-)-Baclofen

(βR)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid

Z1YR DG&1VQ &&(R)-(-)- Form

(-)-Baclofen

Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (βR)-

(R)-(-)-4-Amino-3-(4-chlorophenyl)butanoic acid

(3R)-4-Amino-3-(4-chlorophenyl)butyric acid

(3R)-4-Amino-3-(4-chlorophenyl)butanoic acid

(R)-Baclofen

(R)-4-Amino-3-(4-chlorophenyl)butanoic acid

Arbaclofen

MFCD01321057

(R)-(-)-4-Amino-3-(4-chlorophenyl)butyric acid

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